PMID- 11890874
OWN - NLM
STAT- MEDLINE
DCOM- 20020508
LR  - 20191105
IS  - 1523-3774 (Print)
IS  - 1523-3774 (Linking)
VI  - 4
IP  - 2
DP  - 2002 Apr
TI  - The genetics of systemic sclerosis.
PG  - 99-107
AB  - The etiopathogenesis of systemic sclerosis (SSc) is unclear. With no definitive 
      evidence supporting an environmental cause, recent attention has focused on 
      genetic factors. Familial clustering and ethnic influences have been 
      demonstrated. Human leukocyte antigen (HLA) associations exist but are more 
      related to the presence of particular autoantibodies rather than to the disease. 
      In addition, no single major histocompatibility complex (MHC) allele predisposes 
      to SSc in all ethnic groups. The role of microchimerism in SSc is a novel yet 
      unproven hypothesis that may be related to intergenerational HLA compatibility. 
      Recent studies investigating polymorphisms in genes coding for extracellular 
      matrix proteins and cell-signaling molecules implicate non-MHC areas in SSc 
      pathogenesis. The data reviewed suggest that SSc is a multigenic complex 
      disorder.
FAU - Johnson, Randall W
AU  - Johnson RW
AD  - University of Texas Health Science Center, Department of Internal Medicine, 6431 
      Fannin MSB 5.260, Houston, TX 77030, USA. Frank.C.Arnett@uth.tmc.edu
FAU - Tew, Monty B
AU  - Tew MB
FAU - Arnett, Frank C
AU  - Arnett FC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Rheumatol Rep
JT  - Current rheumatology reports
JID - 100888970
RN  - 0 (Autoantibodies)
RN  - 0 (Cytokines)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-D Antigens)
SB  - IM
MH  - Autoantibodies/genetics
MH  - Cytokines/genetics
MH  - Extracellular Matrix Proteins/genetics
MH  - HLA Antigens/genetics
MH  - HLA-D Antigens/genetics
MH  - Humans
MH  - Polymorphism, Genetic
MH  - Scleroderma, Systemic/ethnology/*genetics
RF  - 81
EDAT- 2002/03/14 10:00
MHDA- 2002/05/09 10:01
CRDT- 2002/03/14 10:00
PHST- 2002/03/14 10:00 [pubmed]
PHST- 2002/05/09 10:01 [medline]
PHST- 2002/03/14 10:00 [entrez]
AID - 10.1007/s11926-002-0004-2 [doi]
PST - ppublish
SO  - Curr Rheumatol Rep. 2002 Apr;4(2):99-107. doi: 10.1007/s11926-002-0004-2.