PMID- 11890995
OWN - NLM
STAT- MEDLINE
DCOM- 20020327
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 133
IP  - 1
DP  - 2002 Feb
TI  - Identification of ins(8;21) with AML1/ETO fusion in acute myelogenous leukemia M2 
      by molecular cytogenetics.
PG  - 83-6
AB  - A high percentage of cases of acute myelogenous leukemia (AML) of the M2 subtype 
      show a rearrangement between the AML1 and ETO genes. The detection of the 
      AML1/ETO fusion has clinical relevance because patients with this subtype have a 
      good prognosis. We present the results of conventional and molecular cytogenetic 
      studies in a patient with acute myelogenous leukemia French-American-British M2 
      classification, who had a complex karyotype involving chromosomes 8 and 21. 
      Dual-color fluorescence in situ hybridization (FISH) using the AML1/ETO probe 
      demonstrated a recombination of both genes on an add(8) chromosome. The use of 
      other FISH probes (CEP8, c-myc and TEL21) and spectral karyotyping indicated that 
      AML1/ETO fusion occurred as a consequence of a previously undescribed 
      ins(8;21)(q22;q22.1q22.3).
FAU - Urioste, M
AU  - Urioste M
AD  - Departamento de Genetica Humana, Programa de Patologia Molecular, Centro Nacional 
      de Investigaciones Oncologicas, Instituto de Salud Carlos III, Madrid, Spain. 
      murioste@cnio.es
FAU - Martinez-Ramirez, A
AU  - Martinez-Ramirez A
FAU - Cigudosa, J C
AU  - Cigudosa JC
FAU - Mateo, M S
AU  - Mateo MS
FAU - Martinez, P
AU  - Martinez P
FAU - Contra, T
AU  - Contra T
FAU - Benitez, J
AU  - Benitez J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (AML1-ETO fusion protein, human)
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (RUNX1 Translocation Partner 1 Protein)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Child
MH  - *Chromosomes, Human, Pair 21
MH  - *Chromosomes, Human, Pair 8
MH  - Core Binding Factor Alpha 2 Subunit
MH  - Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/*genetics/physiopathology
MH  - Oncogene Proteins, Fusion/analysis/*genetics
MH  - Prognosis
MH  - RUNX1 Translocation Partner 1 Protein
MH  - Transcription Factors/analysis/*genetics
EDAT- 2002/03/14 10:00
MHDA- 2002/03/28 10:01
CRDT- 2002/03/14 10:00
PHST- 2002/03/14 10:00 [pubmed]
PHST- 2002/03/28 10:01 [medline]
PHST- 2002/03/14 10:00 [entrez]
AID - S0165460801005556 [pii]
AID - 10.1016/s0165-4608(01)00555-6 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2002 Feb;133(1):83-6. doi: 10.1016/s0165-4608(01)00555-6.