PMID- 11890999
OWN - NLM
STAT- MEDLINE
DCOM- 20020327
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 133
IP  - 1
DP  - 2002 Feb
TI  - Detection of minimal residual disease in peripheral blood stem cells from two 
      acute myeloid leukemia patients with trisomy 8 predicts early relapse after 
      autologous bone marrow transplantation.
PG  - 98-101
AB  - We report two cases of acute myeloid leukemia (AML) French-American-British M4 
      classification with trisomy 8 at diagnosis as the sole chromosome abnormality. 
      Both patients were treated with the GIMEMA AML-10 protocol and underwent 
      autologous bone marrow transplantation (ABMT) in hematologic remission. 
      Peripheral blood stem cells (PBSC), and bone marrow in one patient, were 
      collected after consolidation therapy and tested by fluorescence in situ 
      hybridization (FISH) analysis with an alpha-satellite probe for chromosome 8. It 
      revealed that all samples were positive for minimal residual disease (MRD) as the 
      value of trisomic cells exceeded the mean +3 standard deviations of the controls. 
      ABMT was done following a myeloablative regimen (busulphan/cyclophosphamide) and 
      PBSC were reinfused. Both patients relapsed, 4 and 2 months, respectively, after 
      autotransplant. Although more data are needed, these results suggest that the 
      persistence of MRD, as detected by FISH, in stem cell collections, is associated 
      with a poor outcome in AML patients with trisomy 8 undergoing ABMT.
FAU - Scaravaglio, Patrizia
AU  - Scaravaglio P
AD  - Dipartimento di Scienze Cliniche e Biologiche, Azienda Ospedaliera San Luigi 
      Gonzaga, Orbassano, Torino, Italy.
FAU - Guglielmelli, Tommasina
AU  - Guglielmelli T
FAU - Giugliano, Emilia
AU  - Giugliano E
FAU - Marmont, Filippo
AU  - Marmont F
FAU - Audisio, Ernesta
AU  - Audisio E
FAU - Gallo, Eugenio
AU  - Gallo E
FAU - Saglio, Giuseppe
AU  - Saglio G
FAU - Rege-Cambrin, Giovanna
AU  - Rege-Cambrin G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
CIN - Cancer Genet Cytogenet. 2003 Jan 15;140(2):176. PMID: 12645660
MH  - Acute Disease
MH  - Adult
MH  - *Bone Marrow Transplantation
MH  - *Chromosomes, Human, Pair 8
MH  - Female
MH  - Hematopoietic Stem Cells/pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Leukemia, Myeloid/genetics/pathology/therapy
MH  - Male
MH  - Neoplasm, Residual/*diagnosis/genetics
MH  - Recurrence
MH  - Transplantation, Autologous
MH  - *Trisomy
EDAT- 2002/03/14 10:00
MHDA- 2002/03/28 10:01
CRDT- 2002/03/14 10:00
PHST- 2002/03/14 10:00 [pubmed]
PHST- 2002/03/28 10:01 [medline]
PHST- 2002/03/14 10:00 [entrez]
AID - S0165460801005647 [pii]
AID - 10.1016/s0165-4608(01)00564-7 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2002 Feb;133(1):98-101. doi: 
      10.1016/s0165-4608(01)00564-7.