PMID- 11891272
OWN - NLM
STAT- MEDLINE
DCOM- 20020424
LR  - 20240314
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 99
IP  - 6
DP  - 2002 Mar 19
TI  - Disruption of estrogen receptor beta gene impairs spatial learning in female 
      mice.
PG  - 3996-4001
AB  - Here we provide the first evidence, to our knowledge, that estradiol (E(2)) 
      affects learning and memory via the newly discovered estrogen receptor beta 
      (ERbeta). In this study, ERbeta knockout (ERbetaKO) and wild-type littermates 
      were tested for spatial learning in the Morris water maze after ovariectomy, 
      appropriate control treatment, or one of two physiological doses of E(2). 
      Regardless of treatment, all wild-type females displayed significant learning. 
      However, ERbetaKOs given the low dose of E(2) were delayed in learning 
      acquisition, and ERbetaKOs administered the higher dose of E(2) failed to learn 
      the task. These data show that ERbeta is required for optimal spatial learning 
      and may have implications for hormone replacement therapy in women.
FAU - Rissman, Emilie F
AU  - Rissman EF
AD  - Department of Biology and Internal Medicine, University of Virginia, 
      Charlottesville, VA 22903, USA. efr2@virginia.edu
FAU - Heck, Amy L
AU  - Heck AL
FAU - Leonard, Julie E
AU  - Leonard JE
FAU - Shupnik, Margaret A
AU  - Shupnik MA
FAU - Gustafsson, Jan-Ake
AU  - Gustafsson JA
LA  - eng
GR  - K02 MH01349/MH/NIMH NIH HHS/United States
GR  - K02 MH001349/MH/NIMH NIH HHS/United States
GR  - U54 HD028934/HD/NICHD NIH HHS/United States
GR  - R01 MH057759/MH/NIMH NIH HHS/United States
GR  - U54 HD28934/HD/NICHD NIH HHS/United States
GR  - R01 MH57759/MH/NIMH NIH HHS/United States
GR  - DK57982/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20020312
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Receptors, Estrogen)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects/physiology
MH  - Cues
MH  - Escape Reaction/drug effects/physiology
MH  - Estradiol/blood/*pharmacology
MH  - Estrogen Receptor beta
MH  - Female
MH  - *Gene Deletion
MH  - Hippocampus/drug effects/metabolism
MH  - Learning/*drug effects/physiology
MH  - Maze Learning/drug effects/physiology
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Mice, Knockout
MH  - Organ Size/drug effects
MH  - Ovariectomy
MH  - Receptors, Estrogen/*deficiency/genetics/metabolism
MH  - Space Perception/*drug effects/physiology
MH  - Uterus/drug effects/growth & development
PMC - PMC122637
EDAT- 2002/03/14 10:00
MHDA- 2002/04/25 10:01
PMCR- 2002/09/19
CRDT- 2002/03/14 10:00
PHST- 2002/03/14 10:00 [pubmed]
PHST- 2002/04/25 10:01 [medline]
PHST- 2002/03/14 10:00 [entrez]
PHST- 2002/09/19 00:00 [pmc-release]
AID - 012032699 [pii]
AID - 0326 [pii]
AID - 10.1073/pnas.012032699 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3996-4001. doi: 
      10.1073/pnas.012032699. Epub 2002 Mar 12.