PMID- 11893250
OWN - NLM
STAT- MEDLINE
DCOM- 20020419
LR  - 20190916
IS  - 0033-7587 (Print)
IS  - 0033-7587 (Linking)
VI  - 157
IP  - 4
DP  - 2002 Apr
TI  - Choosing metaphases for biological dosimetry by fluorescence in situ 
      hybridization (FISH).
PG  - 469-71
AB  - Data are presented for a subset of lymphocytes characterized by FISH as missing 
      painted chromosomal material. These lymphocytes occur in both control and 
      irradiated subjects. These cells have a much greater frequency of one-way 
      translocations than cells in which all of the painted chromosomal material is 
      present. Their presence contributes to interindividual variability in control 
      translocation yields. These cells do not appear to be more prevalent in persons 
      exposed to high radiation doses. It is suggested that their exclusion when 
      selecting cells for analysis may improve the sensitivity of FISH as a biological 
      dosimeter at low doses. Mechanisms for the production of these one-way 
      translocations in vivo are also discussed, with a proposal that their variable 
      frequency in individuals may be consistent with exposure to chemical clastogens.
FAU - Edwards, A
AU  - Edwards A
AD  - National Radiological Protection Board, Chilton, Didcot, OX11 0RQ, United 
      Kingdom.
FAU - Maznik, N
AU  - Maznik N
FAU - Moquet, J
AU  - Moquet J
FAU - Hone, P
AU  - Hone P
FAU - Vinnikov, V
AU  - Vinnikov V
FAU - Lloyd, D
AU  - Lloyd D
FAU - Cox, R
AU  - Cox R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiat Res
JT  - Radiation research
JID - 0401245
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Chromosome Aberrations/*radiation effects
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Lymphocytes/*cytology/*radiation effects
MH  - *Metaphase/radiation effects
MH  - Middle Aged
MH  - Radiometry/*methods
MH  - Translocation, Genetic/radiation effects
EDAT- 2002/03/15 10:00
MHDA- 2002/04/20 10:01
CRDT- 2002/03/15 10:00
PHST- 2002/03/15 10:00 [pubmed]
PHST- 2002/04/20 10:01 [medline]
PHST- 2002/03/15 10:00 [entrez]
AID - 10.1667/0033-7587(2002)157[0469:cmfbdb]2.0.co;2 [doi]
PST - ppublish
SO  - Radiat Res. 2002 Apr;157(4):469-71. doi: 
      10.1667/0033-7587(2002)157[0469:cmfbdb]2.0.co;2.