PMID- 11894141
OWN - NLM
STAT- MEDLINE
DCOM- 20020830
LR  - 20110708
IS  - 0946-2716 (Print)
IS  - 0946-2716 (Linking)
VI  - 80
IP  - 3
DP  - 2002 Mar
TI  - Immunoregulatory functions of interleukin 18 and its role in defense against 
      bacterial pathogens.
PG  - 147-62
AB  - Interleukin-18 (IL-18) is a proinflammatory cytokine that belongs to the IL-1 
      cytokine family, due to its structure, receptor family and signal transduction 
      pathways. Similarly to IL-1beta, IL-18 is synthesized as a precursor requiring 
      caspase-1 for cleavage into an active IL-18 molecule. However, with regard to its 
      capacity to induce the production of Th1 cytokines and to enhance cell-mediated 
      cytotoxicity, IL-18 is also related to IL-12. Produced mainly by 
      antigen-presenting cells, IL-18 is a pleiotropic factor involved in the 
      regulation of both innate and acquired immune responses, playing a key role in 
      autoimmune, inflammatory, and infectious diseases. This review summarizes recent 
      advances in the understanding of IL-18 structure, processing, receptor 
      expression, and immunoregulatory functions and emphasizes the critical role of 
      this cytokine in bacterial infections. It focuses on the participation of this 
      cytokine in the defense against intracellular bacteria, including Listeria, 
      Shigella, Salmonella, and Mycobacterium tuberculosis. Since this cytokine may be 
      particularly useful in immunoprophylactic and immunotherapeutic interventions in 
      which the cellular response is most desirable, the potential therapeutic aspects 
      of IL-18 is also discussed.
FAU - Biet, Franck
AU  - Biet F
AD  - Laboratoire de Microbiologie Genetique et Moleculaire, Institut National de la 
      Sante et de la Recherche Medicale U447, Institut Pasteur de Lille, 1 rue du 
      Professeur Calmette, 59021 Lille, France.
FAU - Locht, Camille
AU  - Locht C
FAU - Kremer, Laurent
AU  - Kremer L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20011208
PL  - Germany
TA  - J Mol Med (Berl)
JT  - Journal of molecular medicine (Berlin, Germany)
JID - 9504370
RN  - 0 (IL18R1 protein, human)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-18 Receptor alpha Subunit)
RN  - 0 (Receptors, Interleukin)
RN  - 0 (Receptors, Interleukin-18)
RN  - 187348-17-0 (Interleukin-12)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Bacteria/*immunology
MH  - Bacterial Infections/drug therapy/immunology/metabolism
MH  - Humans
MH  - Interferon-gamma/biosynthesis/metabolism
MH  - Interleukin-1/immunology/metabolism
MH  - Interleukin-12/immunology/metabolism
MH  - Interleukin-18/*immunology/metabolism/therapeutic use
MH  - Interleukin-18 Receptor alpha Subunit
MH  - Receptors, Interleukin/metabolism
MH  - Receptors, Interleukin-18
MH  - Signal Transduction
RF  - 144
EDAT- 2002/03/15 10:00
MHDA- 2002/08/31 10:01
CRDT- 2002/03/15 10:00
PHST- 2001/07/23 00:00 [received]
PHST- 2001/10/05 00:00 [accepted]
PHST- 2002/03/15 10:00 [pubmed]
PHST- 2002/08/31 10:01 [medline]
PHST- 2002/03/15 10:00 [entrez]
AID - 10.1007/s00109-001-0307-1 [doi]
PST - ppublish
SO  - J Mol Med (Berl). 2002 Mar;80(3):147-62. doi: 10.1007/s00109-001-0307-1. Epub 
      2001 Dec 8.