PMID- 11894735
OWN - NLM
STAT- MEDLINE
DCOM- 20020821
LR  - 20161020
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 23
IP  - 1
DP  - 2002 Jan-Feb
TI  - Recombinant allergens for immunotherapy.
PG  - 5-8
AB  - Many of the problems associated with using natural allergenic products for 
      allergy diagnosis and treatment can be overcome using genetically engineered 
      recombinant allergens. Over the past 10 years, the most important allergens from 
      mites, pollens, animal dander, insects, and foods have been cloned, sequenced, 
      and expressed. Allergens have diverse biological functions (they may be enzymes, 
      enzyme inhibitors, lipocalins, or structural proteins). High-level expression 
      systems have been developed to produce recombinant allergens in bacteria, yeast, 
      or insect cells. Recombinant allergens show comparable immunoglobulin E (IgE) 
      antibody binding to natural allergens and show excellent reactivity on skin 
      testing and in in vitro diagnostic tests. Recombinant allergens will enable 
      innovative new strategies for allergen immunotherapy to be developed. These 
      include peptide-based vaccines, engineered hypoallergens with reduced reactivity 
      for IgE antibodies, nucleotide-conjugated vaccines that promote Th1 responses, 
      and the possibility of developing prophylactic allergen vaccines.
FAU - Chapman, Martin D
AU  - Chapman MD
AD  - Asthma and Allergic Diseases Center, Department of Medicine, University of 
      Virginia, Charlottesville, Virginia, USA.
FAU - Smith, Alisa M
AU  - Smith AM
FAU - Vailes, Lisa D
AU  - Vailes LD
FAU - Pomes, Anna
AU  - Pomes A
LA  - eng
GR  - AI 32557/AI/NIAID NIH HHS/United States
GR  - AI 34607/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Allergens)
SB  - IM
MH  - Allergens/*genetics/immunology/*therapeutic use
MH  - *Desensitization, Immunologic
MH  - Humans
MH  - Hypersensitivity/*genetics/immunology/*therapy
MH  - Recombination, Genetic/*genetics/immunology
RF  - 31
EDAT- 2002/03/16 10:00
MHDA- 2002/08/22 10:01
CRDT- 2002/03/16 10:00
PHST- 2002/03/16 10:00 [pubmed]
PHST- 2002/08/22 10:01 [medline]
PHST- 2002/03/16 10:00 [entrez]
PST - ppublish
SO  - Allergy Asthma Proc. 2002 Jan-Feb;23(1):5-8.