PMID- 11895187
OWN - NLM
STAT- MEDLINE
DCOM- 20020903
LR  - 20190910
IS  - 0735-7044 (Print)
IS  - 0735-7044 (Linking)
VI  - 116
IP  - 1
DP  - 2002 Feb
TI  - The entorhinal cortex-nucleus accumbens pathway and latent inhibition: a 
      behavioral and neurochemical study in rats.
PG  - 95-104
AB  - Latent inhibition (LI) refers to the decrease in conditioned response produced by 
      the repeated nonrein-forced preexposure to the to-be-conditioned stimulus. 
      Experiment I investigated the effects of electrolytic lesions of the entorhinal 
      cortex on LI in a conditioned emotional response procedure. Entorhinal cortex 
      lesions attenuated LI. Experiments 2 and 3 investigated whether this attenuation 
      of LI could result from a modification in nucleus accumbens (NAcc) dopamine (DA) 
      release. Rats with entorhinal cortex lesions displayed normal spontaneous and 
      amphetamine-induced locomotor activity, as well as normal basal and 
      amphetamine-induced release of DA within the NAcc (assessed by microdialysis). 
      Taken together, these results show that entorhinal cortex lesions disrupt LI in a 
      way that is unlikely to be due to an alteration of DA release within the NAcc.
FAU - Coutureau, Etienne
AU  - Coutureau E
AD  - Laboratoire de Neurosciences Comportementales et Cognitives, Centre National de 
      la Recherche Scientifique, Universite Louis Pasteur, Strasbourg, France. 
      coutureaue@cardiff.ac.uk
FAU - Lena, Isabelle
AU  - Lena I
FAU - Dauge, Valerie
AU  - Dauge V
FAU - Di Scala, Georges
AU  - Di Scala G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Arousal/physiology
MH  - Conditioning, Classical/*physiology
MH  - Dopamine/*physiology
MH  - Entorhinal Cortex/*physiology
MH  - Fear/physiology
MH  - Male
MH  - Mental Recall/*physiology
MH  - Motor Activity/physiology
MH  - Neural Inhibition/*physiology
MH  - Neural Pathways/physiology
MH  - Nucleus Accumbens/*physiology
MH  - Rats
MH  - Rats, Long-Evans
EDAT- 2002/03/16 10:00
MHDA- 2002/09/11 10:01
CRDT- 2002/03/16 10:00
PHST- 2002/03/16 10:00 [pubmed]
PHST- 2002/09/11 10:01 [medline]
PHST- 2002/03/16 10:00 [entrez]
AID - 10.1037//0735-7044.116.1.95 [doi]
PST - ppublish
SO  - Behav Neurosci. 2002 Feb;116(1):95-104. doi: 10.1037//0735-7044.116.1.95.