PMID- 11895199
OWN - NLM
STAT- MEDLINE
DCOM- 20021022
LR  - 20191105
IS  - 1528-9117 (Print)
IS  - 1528-9117 (Linking)
VI  - 8
IP  - 1
DP  - 2002 Jan-Feb
TI  - Advances in allogeneic stem cell transplantation: directing graft-versus-leukemia 
      at solid tumors.
PG  - 2-11
AB  - Allogeneic stem cell transplantation was originally developed as a method to 
      rescue hematopoietic function following high dose "myeloablative" therapy in the 
      treatment of hematological malignancies. In the first two decades of its use, 
      dose-intensive chemotherapy alone was credited with curing those patients who 
      achieved sustained remission following this procedure. However, more recently 
      investigators have come to recognize that antineoplastic effects mediated by 
      immunocompetent donor T-cells transplanted with the stem cell allograft can be 
      induced against hematological malignancies. Indeed, this graft-vs-leukemia (GVL) 
      or graft-vs-tumor (GVT) effect is now felt to represent the principal modality 
      required to sustain durable remissions of hematological malignancies following 
      this approach. The powerful and potentially curative nature of the GVT effect in 
      hematological cancers has recently lured oncologists into exploring the 
      therapeutic potential of allogeneic stem cell transplantation as an 
      investigational approach for treatment-refractory solid tumors. We review here 
      the development and early clinical results of allogeneic stem cell 
      transplantation as potential immunotherapy for solid tumors.
FAU - Childs, Richard
AU  - Childs R
AD  - Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes 
      of Health, Bethesda, Maryland 20892-1652, USA.
FAU - Srinivasan, Ram
AU  - Srinivasan R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cancer J
JT  - Cancer journal (Sudbury, Mass.)
JID - 100931981
SB  - IM
MH  - Carcinoma, Renal Cell/therapy
MH  - Clinical Protocols
MH  - Graft vs Leukemia Effect/*immunology
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Humans
MH  - Immunotherapy/*methods
MH  - Kidney Neoplasms/therapy
MH  - Neoplasms/*therapy
MH  - Transplantation, Homologous/immunology
RF  - 55
EDAT- 2002/03/16 10:00
MHDA- 2002/10/31 04:00
CRDT- 2002/03/16 10:00
PHST- 2002/03/16 10:00 [pubmed]
PHST- 2002/10/31 04:00 [medline]
PHST- 2002/03/16 10:00 [entrez]
AID - 10.1097/00130404-200201000-00002 [doi]
PST - ppublish
SO  - Cancer J. 2002 Jan-Feb;8(1):2-11. doi: 10.1097/00130404-200201000-00002.