PMID- 11896149
OWN - NLM
STAT- MEDLINE
DCOM- 20020327
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 22
IP  - 6
DP  - 2002 Mar 15
TI  - Impaired spatial cognition and synaptic potentiation in a murine model of human 
      immunodeficiency virus type 1 encephalitis.
PG  - 2096-105
AB  - Injection of human immunodeficiency virus type 1 (HIV-1)-infected human 
      monocyte-derived macrophages (MDMs) into the basal ganglia of severe combined 
      immunodeficient mice recapitulates histopathologic features of HIV-1 encephalitis 
      (HIVE). Here, we show that the neural damage in HIVE mice extends beyond the 
      basal ganglia and is associated with cognitive impairment. Morris water maze 
      tests showed impaired spatial learning 8 d after MDM injection. Moreover, 
      impaired synaptic potentiation in the hippocampal CA1 subregion was demonstrated 
      at 8 and 15 d. By day 15, post-tetanic, short-term, and long-term potentiation 
      were reduced by 14.1, 29.5, and 45.3% in HIVE mice compared with sham-injected or 
      control animals. Neurofilament (NF) and synaptophysin (SP) antigens were 
      decreased significantly in the CA2 hippocampal subregion of HIVE mice with 
      limited neuronal apoptosis. By day 15, the CA2 region of HIVE mice expressed 3.8- 
      and 2.6-fold less NF and SP than shams. These findings support the notion that 
      HIV-1-infected and immune-competent brain macrophages can cause neuronal damage 
      at distant anatomic sites. Importantly, the findings demonstrate the value of the 
      model in exploring the physiological basis and therapeutic potential for 
      HIV-1-associated dementia.
FAU - Zink, Walter E
AU  - Zink WE
AD  - Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska 
      Medical Center, Omaha, Nebraska 68198-5215, USA.
FAU - Anderson, Eric
AU  - Anderson E
FAU - Boyle, Jeffrey
AU  - Boyle J
FAU - Hock, Lynette
AU  - Hock L
FAU - Rodriguez-Sierra, Jorge
AU  - Rodriguez-Sierra J
FAU - Xiong, Huangui
AU  - Xiong H
FAU - Gendelman, Howard E
AU  - Gendelman HE
FAU - Persidsky, Yuri
AU  - Persidsky Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Antigens, Differentiation)
SB  - IM
MH  - AIDS Dementia Complex/complications/*physiopathology/virology
MH  - Animals
MH  - Antigens, Differentiation/biosynthesis
MH  - Basal Ganglia/pathology/physiopathology/virology
MH  - Behavior, Animal
MH  - Cells, Cultured
MH  - Cognition Disorders/etiology/*physiopathology
MH  - Disease Models, Animal
MH  - Disease Progression
MH  - Electric Stimulation
MH  - Evoked Potentials
MH  - HIV-1/*pathogenicity
MH  - Hippocampus/pathology/physiopathology
MH  - Humans
MH  - In Situ Nick-End Labeling
MH  - In Vitro Techniques
MH  - *Long-Term Potentiation
MH  - Macrophages/pathology/transplantation/virology
MH  - Male
MH  - Maze Learning
MH  - Mice
MH  - Mice, SCID
MH  - Neurons/metabolism/pathology
MH  - *Synaptic Transmission
MH  - Transplantation, Heterologous
PMC - PMC6758279
EDAT- 2002/03/16 10:00
MHDA- 2002/03/28 10:01
PMCR- 2002/09/15
CRDT- 2002/03/16 10:00
PHST- 2002/03/16 10:00 [pubmed]
PHST- 2002/03/28 10:01 [medline]
PHST- 2002/03/16 10:00 [entrez]
PHST- 2002/09/15 00:00 [pmc-release]
AID - 22/6/2096 [pii]
AID - 6089 [pii]
AID - 10.1523/JNEUROSCI.22-06-02096.2002 [doi]
PST - ppublish
SO  - J Neurosci. 2002 Mar 15;22(6):2096-105. doi: 10.1523/JNEUROSCI.22-06-02096.2002.