PMID- 11898340
OWN - NLM
STAT- MEDLINE
DCOM- 20020913
LR  - 20210224
IS  - 0015-5632 (Print)
IS  - 0015-5632 (Linking)
VI  - 46
IP  - 6
DP  - 2001
TI  - Phenolic acids reduce the genotoxicity of acridine orange and ofloxacin in 
      Salmonella typhimurium.
PG  - 511-4
AB  - Naturally occurring plant phenolics, p-coumaric acid (PA), caffeic acid (CA), 
      ferulic acid (FA) and gentisic acid (GA) (25-100 nmol/L) had protective effects 
      on acridine orange (AO; 216 mumol/L)- and ofloxacin (3 mumol/L)-induced 
      genotoxicity in Salmonella typhimurium. FA, GA and CA exhibited a significant 
      concentration-dependent protective effect against the genotoxicity of AO and 
      ofloxacin, with the exception of PA, which at all concentrations tested abolished 
      the AO and ofloxacin genotoxicity. UV spectrophotometric measurements showed the 
      interaction of PA, FA, GA and CA with AO but not with ofloxacin; this interaction 
      is obviously responsible for the reduction of AO-induced S. typhimurium 
      mutagenicity. In the case of ofloxacin the antimutagenic effect of PA, FA, GA and 
      CA is assumed to be a result of their ability to scavenge reactive oxygen species 
      (ROS) produced by ofloxacin.
FAU - Belicova, A
AU  - Belicova A
AD  - Institute of Cell Biology, Faculty of Science, Comenius University, 811 07 
      Bratislava, Slovakia. belicova@m2.fedu.uniba.sk
FAU - Krizkova, L
AU  - Krizkova L
FAU - Nagy, M
AU  - Nagy M
FAU - Krajcovic, J
AU  - Krajcovic J
FAU - Ebringer, L
AU  - Ebringer L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Folia Microbiol (Praha)
JT  - Folia microbiologica
JID - 0376757
RN  - 0 (Antimutagenic Agents)
RN  - 0 (Caffeic Acids)
RN  - 0 (Coumaric Acids)
RN  - 0 (Gentisates)
RN  - 0 (Hydroxybenzoates)
RN  - 0 (Mutagens)
RN  - 0 (Propionates)
RN  - A4P49JAZ9H (Ofloxacin)
RN  - AVM951ZWST (ferulic acid)
RN  - F30N4O6XVV (Acridine Orange)
RN  - I3P9R8317T (phenolic acid)
RN  - IBS9D1EU3J (p-coumaric acid)
RN  - U2S3A33KVM (caffeic acid)
RN  - VP36V95O3T (2,5-dihydroxybenzoic acid)
SB  - IM
MH  - Acridine Orange/*toxicity
MH  - Antimutagenic Agents/*pharmacology
MH  - Caffeic Acids/pharmacology
MH  - Coumaric Acids/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - *Gentisates
MH  - Hydroxybenzoates/*pharmacology
MH  - Mutagenicity Tests
MH  - Mutagens/*toxicity
MH  - Ofloxacin/*toxicity
MH  - Propionates
MH  - Salmonella typhimurium/*drug effects/genetics
EDAT- 2002/03/20 10:00
MHDA- 2002/09/14 10:01
CRDT- 2002/03/20 10:00
PHST- 2002/03/20 10:00 [pubmed]
PHST- 2002/09/14 10:01 [medline]
PHST- 2002/03/20 10:00 [entrez]
AID - 10.1007/BF02817994 [doi]
PST - ppublish
SO  - Folia Microbiol (Praha). 2001;46(6):511-4. doi: 10.1007/BF02817994.