PMID- 11898551
OWN - NLM
STAT- MEDLINE
DCOM- 20020409
LR  - 20191105
IS  - 1528-4042 (Print)
IS  - 1528-4042 (Linking)
VI  - 1
IP  - 5
DP  - 2001 Sep
TI  - Frontotemporal dementia and tauopathy.
PG  - 413-21
AB  - The presence of abundant neurofibrillary lesions made of hyperphosphorylated tau 
      proteins is the characteristic neuropathology of a subset of neurodegenerative 
      disorders classified as "tauopathies." The discovery of mutations in the tau gene 
      in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) 
      constitutes convincing evidence that tau proteins play a key role in the 
      pathogenesis of neurodegenerative disorders. Moreover, it now is known that the 
      most common form of sporadic frontotemporal dementia (FTD), which is 
      characterized by frontotemporal neuron loss, gliosis, and microvacuolar change, 
      also is a tauopathy caused by a loss of tau protein expression. Thus, these 
      discoveries have begun to change the classification and the neuropathologic 
      diagnosis of FTD and tauopathies, as well as current understanding of the disease 
      mechanisms underlying them. Although transgenic mice expressing wild-type human 
      tau or variants thereof with an FTDP-17 mutation result in tau pathologies and 
      brain degeneration similar to that seen in human tauopathies, the precise 
      mechanisms leading to the onset and progression of neurodegenerative disorders 
      remain incompletely understood. Here, we review current understanding of human 
      neurodegenerative tauopathies and prospects for translative recent insights about 
      these into therapeutic interventions to prevent or ameliorate them.
FAU - Yoshiyama, Y
AU  - Yoshiyama Y
AD  - Center for Neurodegenerative Research, Department of Pathology and Laboratory 
      Medicine, University of Pennsylvania, 3400 Spruce Street, 3rd Floor Maloney, 
      Philadelphia, PA 19104, USA.
FAU - Lee, V M
AU  - Lee VM
FAU - Trojanowski, J Q
AU  - Trojanowski JQ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Neurol Neurosci Rep
JT  - Current neurology and neuroscience reports
JID - 100931790
RN  - 0 (tau Proteins)
SB  - IM
MH  - Dementia/*genetics/*pathology
MH  - Humans
MH  - Tauopathies/genetics/pathology
MH  - tau Proteins/genetics
RF  - 50
EDAT- 2002/03/20 10:00
MHDA- 2002/04/10 10:01
CRDT- 2002/03/20 10:00
PHST- 2002/03/20 10:00 [pubmed]
PHST- 2002/04/10 10:01 [medline]
PHST- 2002/03/20 10:00 [entrez]
AID - 10.1007/s11910-001-0100-0 [doi]
PST - ppublish
SO  - Curr Neurol Neurosci Rep. 2001 Sep;1(5):413-21. doi: 10.1007/s11910-001-0100-0.