PMID- 11900820
OWN - NLM
STAT- MEDLINE
DCOM- 20031021
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 72
IP  - 1-2
DP  - 2002 May
TI  - Acute nicotine effects on auditory sensory memory in tacrine-treated and 
      nontreated patients with Alzheimer's disease: an event-related potential study.
PG  - 457-64
AB  - The auditory mismatch negativity (MMN) event-related brain potential (ERP) 
      reflects the storage of information in acoustic sensory memory. Thirteen patients 
      with Alzheimer's disease (AD), 6 receiving treatment with the cholinesterase 
      inhibitor, tacrine [tetrahydroaminoacridine (THA)], and 7 receiving no treatment, 
      were administered 2 mg of nicotine polacrilex and placebo. MMNs were recorded 
      with 1- and 3-s interstimulus intervals (ISIs) during pre- and 
      post-placebo/nicotine administration. Amplitudes decreased from pre- to 
      post-placebo recordings in nontreated patients but remained stable in THA-treated 
      patients. Comparison of pre- and post-nicotine MMNs found amplitude increases 
      with nicotine in nontreated but not in THA-treated patients. MMN latencies were 
      shortened by nicotine in both treatment groups. These exploratory findings 
      suggest that nicotine-improved strength of acoustic sensory memory traces and 
      speed of acoustic sensory discrimination in AD are differentially affected by 
      chronic tacrine treatment.
FAU - Engeland, C
AU  - Engeland C
AD  - Department of Psychiatry and Psychology, University of Western Ontario, London, 
      ON, Canada.
FAU - Mahoney, C
AU  - Mahoney C
FAU - Mohr, E
AU  - Mohr E
FAU - Ilivitsky, V
AU  - Ilivitsky V
FAU - Knott, Verner J
AU  - Knott VJ
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 4VX7YNB537 (Tacrine)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Acoustic Stimulation/methods
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*drug therapy/physiopathology/psychology
MH  - Analysis of Variance
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Evoked Potentials, Auditory/*drug effects/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Memory/*drug effects/physiology
MH  - Middle Aged
MH  - Nicotine/*administration & dosage
MH  - Tacrine/*therapeutic use
EDAT- 2002/03/20 10:00
MHDA- 2003/10/22 05:00
CRDT- 2002/03/20 10:00
PHST- 2002/03/20 10:00 [pubmed]
PHST- 2003/10/22 05:00 [medline]
PHST- 2002/03/20 10:00 [entrez]
AID - S0091305702007116 [pii]
AID - 10.1016/s0091-3057(02)00711-6 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2002 May;72(1-2):457-64. doi: 
      10.1016/s0091-3057(02)00711-6.