PMID- 11901838
OWN - NLM
STAT- MEDLINE
DCOM- 20020412
LR  - 20061115
IS  - 1473-7159 (Print)
IS  - 1473-7159 (Linking)
VI  - 1
IP  - 3
DP  - 2001 Sep
TI  - Endocrine tumors of the digestive tract and pancreas: histogenesis, diagnosis and 
      molecular basis.
PG  - 323-33
AB  - Although relatively rare, endocrine tumors of the digestive tract and pancreas 
      have been widely investigated and represent a complex tumor entity. The two major 
      categories of well-differentiated and poorly differentiated tumors show important 
      phenotypic and clinical differences. In well-differentiated tumors the multiple 
      endocrine neoplasia syndrome of Type 1 (MEN1) gene is frequently abnormal, though 
      a complex multiple gene involvement is postulated for different tumor types. 
      Poorly differentiated carcinomas show frequent p53 gene hyperexpression/defects, 
      characterizing severe cell abnormality and possibly accounting for the malignancy 
      of such carcinomas.
FAU - Rindi, G
AU  - Rindi G
AD  - Department of Pathology, Universita di Brescia-Spedali, Civili, Anatomia 
      Patologica 2, Piazza Spedali Civili 1, I-25124 Brescia, Italy. 
      rindi@master.cci.unibs.it
FAU - Villanacci, V
AU  - Villanacci V
FAU - Ubiali, A
AU  - Ubiali A
FAU - Scarpa, A
AU  - Scarpa A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Expert Rev Mol Diagn
JT  - Expert review of molecular diagnostics
JID - 101120777
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Cell Differentiation
MH  - Genes, p53/genetics
MH  - Humans
MH  - Intestinal Neoplasms/diagnosis/*genetics
MH  - Mutation
MH  - Neoplasm Proteins/genetics
MH  - Pancreas/pathology
MH  - Pancreatic Neoplasms/diagnosis/*genetics
MH  - *Proto-Oncogene Proteins
MH  - Stomach Neoplasms/diagnosis/*genetics
RF  - 89
EDAT- 2002/03/21 10:00
MHDA- 2002/04/16 10:01
CRDT- 2002/03/21 10:00
PHST- 2002/03/21 10:00 [pubmed]
PHST- 2002/04/16 10:01 [medline]
PHST- 2002/03/21 10:00 [entrez]
AID - ERM010313 [pii]
AID - 10.1586/14737159.1.3.323 [doi]
PST - ppublish
SO  - Expert Rev Mol Diagn. 2001 Sep;1(3):323-33. doi: 10.1586/14737159.1.3.323.