PMID- 11902144
OWN - NLM
STAT- MEDLINE
DCOM- 20021002
LR  - 20190910
IS  - 1045-3873 (Print)
IS  - 1045-3873 (Linking)
VI  - 13
IP  - 2
DP  - 2002 Feb
TI  - Novel electrophysiologic parameter of dispersion of atrial repolarization: 
      comparison of different atrial pacing methods.
PG  - 110-7
AB  - INTRODUCTION: Heterogeneity of ventricular repolarization plays a major role in 
      reentrant tachyarrhythmias in cardiac tissue. However, the role of atrial 
      repolarization added activation time (AT) to refractoriness in atrial 
      vulnerability has not been investigated in detail. METHODS AND RESULTS: The study 
      population consisted of 34 patients: 18 with atrial fibrillation (AF) and 16 
      without AF (control group). The effective refractory periods (ERPs) in the right 
      atrial appendage, low lateral right atrium, high right septum, and distal 
      coronary sinus, and ATs from P wave onset to each electrogram during sinus rhythm 
      and right atrial appendage, low lateral right atrial, high right septal, distal 
      coronary sinus, and biatrial pacing were measured. Atrial recovery time, defined 
      as the sum of AT and ERP, and its dispersions during sinus rhythm, right atrial 
      appendage, low lateral right atrial, high right septal, distal coronary sinus, 
      and biatrial pacing were calculated. Both ERP dispersion and atrial recovery time 
      dispersion during sinus rhythm were significantly greater in the AF group than in 
      the control group. Atrial recovery time dispersion during distal coronary sinus, 
      high right septal, or biatrial pacing was significantly smaller than that during 
      right atrial appendage or low lateral right atrial pacing in each group. In 
      particular, atrial recovery time dispersion during distal coronary sinus pacing 
      was the smallest of the five pacing methods in the AF group. P wave duration 
      during biatrial or high right septal pacing was significantly shorter than during 
      right atrial appendage, low lateral right atrial, or distal coronary sinus pacing 
      in each group. CONCLUSION: Atrial recovery time dispersion is suitable as an 
      electrophysiologic parameter of atrial vulnerability. Distal coronary sinus 
      pacing may prevent AF by increasing homogeneity of atrial repolarization, whereas 
      biatrial and high right septal pacing contribute not only homogeneity of atrial 
      repolarization but also improvement of atrial depolarization.
FAU - Ogawa, Masahiro
AU  - Ogawa M
AD  - Department of Cardiology, Fukuoka University School of Medicine, Japan. 
      ogawamas@kc4.so-net.ne.jp
FAU - Kumagai, Koichiro
AU  - Kumagai K
FAU - Gondo, Naoki
AU  - Gondo N
FAU - Matsumoto, Naomichi
AU  - Matsumoto N
FAU - Suyama, Kazuhiro
AU  - Suyama K
FAU - Saku, Keijiro
AU  - Saku K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Cardiovasc Electrophysiol
JT  - Journal of cardiovascular electrophysiology
JID - 9010756
SB  - IM
MH  - Atrial Appendage/*physiopathology
MH  - Atrial Fibrillation/*prevention & control
MH  - Cardiac Pacing, Artificial/*methods
MH  - Chi-Square Distribution
MH  - Electrophysiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Refractory Period, Electrophysiological
EDAT- 2002/03/21 10:00
MHDA- 2002/10/03 04:00
CRDT- 2002/03/21 10:00
PHST- 2002/03/21 10:00 [pubmed]
PHST- 2002/10/03 04:00 [medline]
PHST- 2002/03/21 10:00 [entrez]
AID - 10.1046/j.1540-8167.2002.00110.x [doi]
PST - ppublish
SO  - J Cardiovasc Electrophysiol. 2002 Feb;13(2):110-7. doi: 
      10.1046/j.1540-8167.2002.00110.x.