PMID- 11902311
OWN - NLM
STAT- MEDLINE
DCOM- 20020422
LR  - 20190916
IS  - 1077-4114 (Print)
IS  - 1077-4114 (Linking)
VI  - 23
IP  - 9
DP  - 2001 Dec
TI  - Herpesvirus-6 encephalitis complicated by Wernicke-Korsakoff syndrome in a 
      pediatric recipient of unrelated cord blood transplantation.
PG  - 626-8
AB  - A 10-year-old girl with M2 acute myeloid leukemia underwent an unrelated cord 
      blood transplantation in refractory first relapse. On day +13, after 48 hours 
      with fever, she showed a measles-like rash, and on day +15, she began 
      experiencing neurologic symptoms (headache, tremors, weakness, nystagmus, mild 
      confusion, speaking, taste, and behavior disturbances, and focal seizures). She 
      also had amnesia for recent events with disability to learn, mimicking 
      Wernicke-Korsakoff syndrome. Computed tomography of the brain and cerebrospinal 
      fluid (CSF) and electroencephalogram were nonspecific. We found human herpesvirus 
      6 (HHV-6) DNA in CSF and cytomegalovirus in bronchoalveolar lavage using 
      polymerase chain reaction techniques. Treatment with ganciclovir and foscarnet 
      was effective, with total resolution of symptoms.
FAU - Carvajal, E
AU  - Carvajal E
AD  - Unidad de Oncologia Pediatrica, Hospital Infantil La Fe, Valencia, Spain.
FAU - Verdeguer, A
AU  - Verdeguer A
FAU - Fernandez, J M
AU  - Fernandez JM
FAU - Canete, A
AU  - Canete A
FAU - Castel, V
AU  - Castel V
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Pediatr Hematol Oncol
JT  - Journal of pediatric hematology/oncology
JID - 9505928
RN  - 0 (Antiviral Agents)
RN  - 04079A1RDZ (Cytarabine)
RN  - 364P9RVW4X (Foscarnet)
RN  - 6PLQ3CP4P3 (Etoposide)
RN  - P9G3CKZ4P5 (Ganciclovir)
RN  - ZS7284E0ZP (Daunorubicin)
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Antiviral Agents/therapeutic use
MH  - Child
MH  - Combined Modality Therapy
MH  - Cytarabine/administration & dosage
MH  - Daunorubicin/administration & dosage
MH  - Encephalitis, Viral/drug therapy/*etiology
MH  - Etoposide/administration & dosage
MH  - Fatal Outcome
MH  - Female
MH  - Fetal Blood/cytology
MH  - Foscarnet/therapeutic use
MH  - Ganciclovir/therapeutic use
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Herpesvirus 6, Human/*isolation & purification/physiology
MH  - Humans
MH  - Immunocompromised Host
MH  - Korsakoff Syndrome/*etiology
MH  - Leukemia, Myeloid, Acute/*complications/drug therapy/therapy
MH  - Recurrence
MH  - Roseolovirus Infections/drug therapy/*etiology
MH  - Transplantation Conditioning/adverse effects
MH  - Transplantation, Homologous/adverse effects
MH  - Virus Activation
EDAT- 2002/03/21 10:00
MHDA- 2002/04/23 10:01
CRDT- 2002/03/21 10:00
PHST- 2002/03/21 10:00 [pubmed]
PHST- 2002/04/23 10:01 [medline]
PHST- 2002/03/21 10:00 [entrez]
AID - 10.1097/00043426-200112000-00016 [doi]
PST - ppublish
SO  - J Pediatr Hematol Oncol. 2001 Dec;23(9):626-8. doi: 
      10.1097/00043426-200112000-00016.