PMID- 11902825
OWN - NLM
STAT- MEDLINE
DCOM- 20020430
LR  - 20220227
IS  - 0008-8749 (Print)
IS  - 0008-8749 (Linking)
VI  - 214
IP  - 1
DP  - 2001 Nov 25
TI  - Natural killer cells express estrogen receptor-alpha and estrogen receptor-beta 
      and can respond to estrogen via a non-estrogen receptor-alpha-mediated pathway.
PG  - 12-20
AB  - Natural killer (NK) cells play a crucial role in host defense against pathogens 
      and immune surveillance against cancer. Given that estrogens have been reported 
      to suppress NK cell activity, we sought to elucidate the mechanisms by which 
      estrogen mediates this effect. We demonstrate by immunocytochemical staining with 
      estrogen receptor-alpha (ERalpha)- and estrogen receptor-beta (ERbeta)-specific 
      antibodies that both ERalpha and ERbeta are expressed in murine NK cells. We also 
      compared the ability of high doses of 17beta-estradiol ( approximately 800 pg/ml) 
      to regulate NK cell activity in wild-type and estrogen receptor-alpha-deficient 
      (ERalphaKO) mice. 17beta-estradiol elicited a significant decrease in NK cell 
      activity in both wild-type and ERalphaKO mice (P < 0.001). These data suggest 
      that ERbeta or possibly a novel receptor is involved in mediating estrogen action 
      on NK cell activity and raise the potential for therapeutic modulation of NK cell 
      activity with selective estrogen receptor modulators (SERMS).
FAU - Curran, E M
AU  - Curran EM
AD  - Department of Veterinary Pathobiology, University of Missouri-Columbia, Columbia, 
      Missouri 65211-5130, USA.
FAU - Berghaus, L J
AU  - Berghaus LJ
FAU - Vernetti, N J
AU  - Vernetti NJ
FAU - Saporita, A J
AU  - Saporita AJ
FAU - Lubahn, D B
AU  - Lubahn DB
FAU - Estes, D M
AU  - Estes DM
LA  - eng
GR  - P01ES10535-01/ES/NIEHS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Cell Immunol
JT  - Cellular immunology
JID - 1246405
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Receptors, Estrogen)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Cytotoxicity Tests, Immunologic
MH  - Estradiol/*pharmacology
MH  - Estrogen Receptor alpha
MH  - Estrogen Receptor beta
MH  - Immunohistochemistry
MH  - Killer Cells, Natural/drug effects/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Receptors, Estrogen/genetics/immunology/*metabolism
MH  - Signal Transduction
MH  - Tumor Cells, Cultured
EDAT- 2002/03/21 10:00
MHDA- 2002/05/01 10:01
CRDT- 2002/03/21 10:00
PHST- 2002/03/21 10:00 [pubmed]
PHST- 2002/05/01 10:01 [medline]
PHST- 2002/03/21 10:00 [entrez]
AID - S0008-8749(02)91886-1 [pii]
AID - 10.1006/cimm.2002.1886 [doi]
PST - ppublish
SO  - Cell Immunol. 2001 Nov 25;214(1):12-20. doi: 10.1006/cimm.2002.1886.