PMID- 11903818
OWN - NLM
STAT- MEDLINE
DCOM- 20020805
LR  - 20190916
IS  - 0904-2512 (Print)
IS  - 0904-2512 (Linking)
VI  - 31
IP  - 3
DP  - 2002 Mar
TI  - Comparison of HPV infection, p53 mutation and allelic losses in post-transplant 
      and non-posttransplant oral squamous cell carcinomas.
PG  - 134-41
AB  - BACKGROUND: Oral squamous cell carcinoma (SCC) is increasingly found in 
      transplant recipients, although little is known of the natural history of the 
      disease or the mechanism underlying this increase. METHODS: In this article we 
      describe the history of development of 5 oral post-transplant SCCs (PSCCs) and 
      compare their genetic profiles to 34 non-posttransplant SCCs (NPSCCs). RESULTS: 
      Of the five patients with PSCCs, 3 had bone marrow transplants and two, kidney. 
      All three PSCCs from bone marrow recipients were preceded locally by 
      graft-vs.-host disease (GVHD). Two of the GVHD were biopsied and demonstrated 
      dysplasia. Similar frequencies of loss of heterozygosity (LOH) occurred in PSCCs 
      and NPSCCs at 3p, 9p, 17p and 8p, with lower frequencies in PSCCs at 4q (39% vs. 
      0%), 11q (53% vs. 20%) and 13q (45% vs. 20%), although the latter were not 
      significantly different. Only 1 PSCC had a p53 mutation, compared to historical 
      values of 40-60% for NPSCC. Interestingly, human papillomavirus (HPV) DNA was 
      detected in 3 (60%) PSCCs, in comparison to only 4 (12%) of the 34 NPSCCs (P = 
      0.0346). CONCLUSIONS: Dysplasia in oral GVHD may be a strong indicator of cancer 
      risk and should not be regarded as reactive changes to lichenoid mucosites. The 
      low level of p53 mutation and increased HPV infection support the involvement of 
      HPV in the development of PSCC, while the similarity in LOH patterns suggests 
      that other aspects of carcinogenesis may be comparable in these two types of 
      SCCs.
FAU - Zhang, L
AU  - Zhang L
AD  - Faculty of Dentistry, University of British Columbia, Canada.
FAU - Epstein, J B
AU  - Epstein JB
FAU - Poh, C F
AU  - Poh CF
FAU - Berean, K
AU  - Berean K
FAU - Lam, W L
AU  - Lam WL
FAU - Zhang, X
AU  - Zhang X
FAU - Rosin, M P
AU  - Rosin MP
LA  - eng
GR  - R01 DE13124-01/DE/NIDCR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Denmark
TA  - J Oral Pathol Med
JT  - Journal of oral pathology & medicine : official publication of the International 
      Association of Oral Pathologists and the American Academy of Oral Pathology
JID - 8911934
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bone Marrow Transplantation/*adverse effects
MH  - Carcinoma, Squamous Cell/*genetics/*virology
MH  - DNA Mutational Analysis
MH  - DNA, Viral/analysis
MH  - Genes, p53/*genetics
MH  - Graft vs Host Disease/*complications/etiology/pathology
MH  - Humans
MH  - Kidney Transplantation/*adverse effects
MH  - Loss of Heterozygosity
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*genetics/*virology
MH  - Papillomaviridae/genetics/isolation & purification
MH  - Papillomavirus Infections/*complications
MH  - Tumor Virus Infections/*complications
EDAT- 2002/03/21 10:00
MHDA- 2002/08/06 10:01
CRDT- 2002/03/21 10:00
PHST- 2002/03/21 10:00 [pubmed]
PHST- 2002/08/06 10:01 [medline]
PHST- 2002/03/21 10:00 [entrez]
AID - jop310302 [pii]
AID - 10.1034/j.1600-0714.2002.310302.x [doi]
PST - ppublish
SO  - J Oral Pathol Med. 2002 Mar;31(3):134-41. doi: 10.1034/j.1600-0714.2002.310302.x.