PMID- 11906529
OWN - NLM
STAT- MEDLINE
DCOM- 20020523
LR  - 20190815
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 15
IP  - 5
DP  - 2002 Mar
TI  - Group III metabotropic glutamate receptors and D1-like and D2-like dopamine 
      receptors interact in the rat nucleus accumbens to influence locomotor activity.
PG  - 869-75
AB  - Evidence for functional interactions between metabotropic glutamate (mGlu) 
      receptors and dopamine (DA) neurotransmission is now clearly established. In the 
      present study, we investigated interactions between group III mGlu receptors and 
      D1- and D2-like receptors in the nucleus accumbens (NAcc). Administration, into 
      the NAcc, of the selective group III mGlu receptor agonist, AP4, resulted in an 
      increase in locomotor activity, which was blocked by pretreatment with the group 
      III mGlu receptor antagonist, MPPG. In addition, pretreatment with AP4 further 
      blocked the increase in motor activity induced by the D1-like receptor agonist, 
      SKF 38393, but potentiated the locomotor responses induced by either the D2-like 
      receptor agonist, quinpirole, or coinfusion of SKF 38393 and quinpirole. MPPG 
      reversed the effects of AP4 on the motor responses induced by D1-like and/or 
      D2-like receptor activation. These results confirm that glutamate transmission 
      may control DA-dependent locomotor function through mGlu receptors and further 
      indicate that group III mGlu receptors oppose the behavioural response produced 
      by D1-like receptor activation and favour those produced by D2-like receptor 
      activation.
FAU - David, Helene N
AU  - David HN
AD  - UMR CNRS 6551, Centre CYCERON, BP 5229, Universite de Caen Basse-Normandie, 
      Boulevard Henri Becquerel, 14074 Caen cedex, France.
FAU - Abraini, Jacques H
AU  - Abraini JH
LA  - eng
PT  - Journal Article
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Dopamine Agonists)
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, Dopamine D1)
RN  - 0 (Receptors, Dopamine D2)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Dopamine/metabolism
MH  - Dopamine Agonists/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions/physiology
MH  - Excitatory Amino Acid Agonists/pharmacology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Glutamic Acid/metabolism
MH  - Male
MH  - Motor Activity/drug effects/*physiology
MH  - Neurons/drug effects/*metabolism
MH  - Nucleus Accumbens/cytology/drug effects/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine D1/agonists/*metabolism
MH  - Receptors, Dopamine D2/agonists/*metabolism
MH  - Receptors, Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism
MH  - Synaptic Transmission/drug effects/*physiology
EDAT- 2002/03/22 10:00
MHDA- 2002/05/25 10:01
CRDT- 2002/03/22 10:00
PHST- 2002/03/22 10:00 [pubmed]
PHST- 2002/05/25 10:01 [medline]
PHST- 2002/03/22 10:00 [entrez]
AID - 1919 [pii]
AID - 10.1046/j.1460-9568.2002.01919.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2002 Mar;15(5):869-75. doi: 10.1046/j.1460-9568.2002.01919.x.