PMID- 11906695
OWN - NLM
STAT- MEDLINE
DCOM- 20020408
LR  - 20190822
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 33
IP  - 6
DP  - 2002 Mar 14
TI  - Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal 
      convergence, of primary accessory olfactory neurons.
PG  - 877-92
AB  - The mechanisms that underlie axonal pathfinding of vomeronasal neurons from the 
      vomeronasal organ (VNO) in the periphery to select glomeruli in the accessory 
      olfactory bulb (AOB) are not well understood. Neuropilin-2, a receptor for 
      secreted semaphorins, is expressed in V1R- and V3R-expressing, but not 
      V2R-expressing, postnatal vomeronasal neurons. Analysis of the vomeronasal nerve 
      in neuropilin-2 (npn-2) mutant mice reveals pathfinding defects at multiple 
      choice points. Vomeronasal sensory axons are severely defasciculated and a subset 
      innervates the main olfactory bulb (MOB). While most axons of V1R-expressing 
      neurons reach the AOB and converge into distinct glomeruli in stereotypic 
      locations, they are no longer restricted to their normal anterior AOB target 
      zone. Thus, Npn-2 and candidate pheromone receptors play distinct and 
      complementary roles in promoting the wiring and patterning of sensory neurons in 
      the accessory olfactory system.
FAU - Cloutier, Jean Francois
AU  - Cloutier JF
AD  - Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 
      North Wolfe Street, Baltimore, MD 21205, USA.
FAU - Giger, Roman J
AU  - Giger RJ
FAU - Koentges, Georgy
AU  - Koentges G
FAU - Dulac, Catherine
AU  - Dulac C
FAU - Kolodkin, Alex L
AU  - Kolodkin AL
FAU - Ginty, David D
AU  - Ginty DD
LA  - eng
GR  - R01MH59199/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Ligands)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 144713-63-3 (Neuropilin-1)
SB  - IM
MH  - Animals
MH  - Axons/*metabolism
MH  - Embryo, Mammalian/anatomy & histology/physiology
MH  - In Situ Hybridization
MH  - Ligands
MH  - Membrane Glycoproteins/genetics/metabolism
MH  - Membrane Proteins/genetics/metabolism
MH  - Mice
MH  - Mice, Transgenic
MH  - Nerve Growth Factors/metabolism
MH  - Nerve Tissue Proteins/genetics/*metabolism
MH  - Neuropilin-1
MH  - Olfactory Bulb/cytology/growth & development/physiology
MH  - Olfactory Receptor Neurons/cytology/*metabolism
MH  - Rats
MH  - Receptors, Cell Surface/genetics/metabolism
MH  - Vomeronasal Organ/cytology/*metabolism
EDAT- 2002/03/22 10:00
MHDA- 2002/04/12 10:01
CRDT- 2002/03/22 10:00
PHST- 2002/03/22 10:00 [pubmed]
PHST- 2002/04/12 10:01 [medline]
PHST- 2002/03/22 10:00 [entrez]
AID - S0896627302006359 [pii]
AID - 10.1016/s0896-6273(02)00635-9 [doi]
PST - ppublish
SO  - Neuron. 2002 Mar 14;33(6):877-92. doi: 10.1016/s0896-6273(02)00635-9.