PMID- 11908732
OWN - NLM
STAT- MEDLINE
DCOM- 20030729
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 43
IP  - 1
DP  - 2002 Jan
TI  - Pentasomy 8q resulting from duplication of isochromosome 8q in chronic 
      myelomonocytic leukemia.
PG  - 207-10
AB  - We report an interesting case of chronic myelomonocytic leukemia (CMML) with 
      pentasomy 8q resulting from the duplication of isochromosome 8q in a 47-year-old 
      male. His blood picture and myelogram showed CMML and the chromosome study, using 
      R-banding and G-banding techniques, revealed a karyotype of 
      47,XY,-8,+i(8)(q10)x2. Dual-color fluorescence in situ hybridization (FISH) 
      studies with a #8 centromeric probe and a locus-specific probe for C-myc gene 
      completely confirmed the result of the conventional cytogenetic method. Reverse 
      transcription polymerase reaction (RT-PCR) revealed no BCR/ABL fusion transcript. 
      Hydroxyurea and 6-mercaptopurine therapy did not induce a complete remission and 
      five months later he died of exacerbation of his disease. On reviewing another 
      two cases with pentasomy 8q in the literature, we feel that pentasomy 8q, when 
      present as a sole anomaly, may play a specific role in leukemogenesis and in 
      determining the clinical characteristics such as monocytic involvement and poor 
      prognosis.
FAU - Shen, Yongmei
AU  - Shen Y
AD  - Leukemia Research Unit, Jiangsu Institute of Hematology, First Affiliated 
      Hospital of Soochow University, Suzhou, People's Republic of China.
FAU - Xue, Yongquan
AU  - Xue Y
FAU - Li, Jianyong
AU  - Li J
FAU - Guo, Yu
AU  - Guo Y
FAU - Wu, Yafang
AU  - Wu Y
FAU - Pan, Jinlan
AU  - Pan J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - E7WED276I5 (Mercaptopurine)
RN  - X6Q56QN5QC (Hydroxyurea)
SB  - IM
MH  - *Aneuploidy
MH  - *Chromosomes, Human, Pair 8
MH  - Cytogenetic Analysis
MH  - Fatal Outcome
MH  - Gene Duplication
MH  - Humans
MH  - Hydroxyurea/administration & dosage
MH  - *Isochromosomes
MH  - Leukemia, Myelomonocytic, Chronic/etiology/*genetics
MH  - Male
MH  - Mercaptopurine/administration & dosage
MH  - Middle Aged
EDAT- 2002/03/23 10:00
MHDA- 2003/07/30 05:00
CRDT- 2002/03/23 10:00
PHST- 2002/03/23 10:00 [pubmed]
PHST- 2003/07/30 05:00 [medline]
PHST- 2002/03/23 10:00 [entrez]
AID - 10.1080/10428190210185 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2002 Jan;43(1):207-10. doi: 10.1080/10428190210185.