PMID- 11908904
OWN - NLM
STAT- MEDLINE
DCOM- 20021008
LR  - 20220311
IS  - 0024-4201 (Print)
IS  - 0024-4201 (Linking)
VI  - 37
IP  - 2
DP  - 2002 Feb
TI  - Dietary cis and trans monounsaturated and saturated FA and plasma lipids and 
      lipoproteins in men.
PG  - 123-31
AB  - Trans monounsaturated fatty acids (TFA) are hypercholesterolemic compared to 
      oleic acid to a degree approaching or equivalent to saturated FA. However, it is 
      unknown to what extent these effects may be due to cholesterol lowering by oleic 
      acid rather than elevation by saturated FA and TFA. In order to better understand 
      the impact of replacing TFA in foods, it is first necessary to know the relative 
      lipid-modifying effects of the major FA that change as TFA are lowered or 
      removed. For 5 wk, 50 normocholesterolemic men were fed controlled diets 
      providing approximately 15% of energy from protein, 39% from fat, and 46% from 
      carbohydrate in a randomized, 6 x 6, crossover design. Eight percent of energy 
      was replaced across diets with the following: carbohydrate (CHO) (1:1 simple to 
      complex); oleic acid (OL); TFA; stearic acid (STE); TFA/STE (4% of energy from 
      each); carbon 12:0-16:0 saturated FA (LMP). LDL cholesterol concentrations 
      (mmol/L) were as follows (different superscripts indicate significance at P < or 
      = 0.01): OL 2.95a; CHO 3.05a,b; STE 3.10b,c; LMP 3.21c,d; TFA + STE 3.32d,e; and 
      TFA 3.36e. HDL cholesterol concentrations (mmol/L) were as allows: STE 1.16a; TFA 
      1.16a,b; TFA/STE 1.17a,b; CHO 1.19b; OL 1.24c; and LMP 1.30d. Triacylglycerides 
      were highest after STE (1.13) and lowest after OL (0.88) (P < 0.001). Thus, 
      compared to the carbohydrate control diet, TFA raised LDL cholesterol at least 
      equivalent to LMP but had no effect on HDL cholesterol; STE had no effect on LDL 
      cholesterol but lowered HDL cholesterol; LMP raised both LDL cholesterol and HDL 
      cholesterol; and oleic acid raised HDL cholesterol but had no effect on LDL 
      cholesterol.
FAU - Judd, Joseph T
AU  - Judd JT
AD  - Beltsville Human Nutrition Research Center, ARS, USDA, Maryland 20705, USA. 
      judd@bhnrc.arsusda.gov
FAU - Baer, David J
AU  - Baer DJ
FAU - Clevidence, Beverly A
AU  - Clevidence BA
FAU - Kris-Etherton, Penny
AU  - Kris-Etherton P
FAU - Muesing, Richard A
AU  - Muesing RA
FAU - Iwane, Marika
AU  - Iwane M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Lipids
JT  - Lipids
JID - 0060450
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Lipids)
RN  - 0 (Lipoproteins)
SB  - IM
MH  - Cross-Over Studies
MH  - Dietary Fats/*administration & dosage
MH  - Dietary Fats, Unsaturated/*administration & dosage
MH  - Energy Intake
MH  - Humans
MH  - Lipids/*blood/classification
MH  - Lipoproteins/*blood/classification
MH  - Male
EDAT- 2002/03/23 10:00
MHDA- 2002/10/09 04:00
CRDT- 2002/03/23 10:00
PHST- 2002/03/23 10:00 [pubmed]
PHST- 2002/10/09 04:00 [medline]
PHST- 2002/03/23 10:00 [entrez]
AID - 10.1007/s11745-002-0871-9 [doi]
PST - ppublish
SO  - Lipids. 2002 Feb;37(2):123-31. doi: 10.1007/s11745-002-0871-9.