PMID- 11909612
OWN - NLM
STAT- MEDLINE
DCOM- 20020626
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 438
IP  - 3
DP  - 2002 Mar 8
TI  - Hyperglycemia induced by intracerebroventricular choline: involvement of the 
      sympatho-adrenal system.
PG  - 197-205
AB  - Intracerebroventricular (i.c.v.) injection of choline (75-300 microg) produced a 
      dose-dependent increase in blood glucose levels. Pre-treatment with the nicotinic 
      acetylcholine receptor antagonist, mecamylamine (50 microg, i.c.v.) blocked the 
      hyperglycemia induced by choline (150 microg, i.c.v.), but the response was not 
      affected by pre-treatment with the muscarinic acetylcholine receptor antagonist, 
      atropine (10 microg, i.c.v.). Pre-treatment with the neuronal choline uptake 
      inhibitor, hemicholinium-3 (20 microg, i.c.v.), attenuated the hyperglycemia 
      induced by choline. The hyperglycemic response to choline was associated 
      increased plasma levels of adrenaline and noradrenaline. The hyperglycemia 
      elicited by choline was greatly attenuated by bilateral adrenalectomy, and 
      entirely blocked by either surgical transection of the splanchnic nerves or by 
      pre-treatment with the alpha-adrenoceptor antagonist, phentolamine. These data 
      show that choline, a precursor of acetylcholine, increases blood glucose and this 
      effect is mediated by central nicotinic acetylcholine receptor activation. An 
      increase in sympatho-adrenal activity appears to be involved in the hyperglycemic 
      effect of choline.
FAU - Gurun, M Sibel
AU  - Gurun MS
AD  - Department of Pharmacology and Clinical Pharmacology, Uludag University Medical 
      School, Bursa, Turkey.
FAU - Ilcol, Yesim Ozarda
AU  - Ilcol YO
FAU - Taga, Yavuz
AU  - Taga Y
FAU - Ulus, Ismail H
AU  - Ulus IH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Blood Glucose)
RN  - 0 (Cholinergic Agents)
RN  - 0 (Nicotinic Antagonists)
RN  - 312-45-8 (Hemicholinium 3)
RN  - 6EE945D3OK (Mecamylamine)
RN  - 7C0697DR9I (Atropine)
RN  - 9Y8NXQ24VQ (Propranolol)
RN  - N91BDP6H0X (Choline)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
RN  - Z468598HBV (Phentolamine)
SB  - IM
MH  - Adrenal Glands/drug effects/physiology
MH  - Adrenalectomy
MH  - Animals
MH  - Atropine/pharmacology
MH  - Blood Glucose/*drug effects/metabolism
MH  - Choline/*pharmacology
MH  - Cholinergic Agents/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Epinephrine/blood
MH  - Hemicholinium 3/pharmacology
MH  - Hyperglycemia/*chemically induced
MH  - Injections, Intraventricular
MH  - Male
MH  - Mecamylamine/pharmacology
MH  - Nicotinic Antagonists/pharmacology
MH  - Norepinephrine/blood
MH  - Phentolamine/pharmacology
MH  - Propranolol/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Sympathetic Nervous System/drug effects/physiology
MH  - Time Factors
EDAT- 2002/03/23 10:00
MHDA- 2002/06/27 10:01
CRDT- 2002/03/23 10:00
PHST- 2002/03/23 10:00 [pubmed]
PHST- 2002/06/27 10:01 [medline]
PHST- 2002/03/23 10:00 [entrez]
AID - S0014299902013122 [pii]
AID - 10.1016/s0014-2999(02)01312-2 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2002 Mar 8;438(3):197-205. doi: 10.1016/s0014-2999(02)01312-2.