PMID- 11909652
OWN - NLM
STAT- MEDLINE
DCOM- 20020604
LR  - 20201208
IS  - 0379-0738 (Print)
IS  - 0379-0738 (Linking)
VI  - 125
IP  - 2-3
DP  - 2002 Feb 18
TI  - Quantitative determination of amphetamines, cocaine, and opiates in human hair by 
      gas chromatography/mass spectrometry.
PG  - 120-6
AB  - Hair of young subjects (N = 36) suspected for drug abuse was analysed for 
      morphine, codeine, heroin, 6-acetylmorphine, cocaine, methadone, amphetamine, 
      methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 
      3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine 
      (MDEA). The analysis of morphine, codeine, heroin, 6-acetylmorphine, cocaine, and 
      methadone in hair included incubation in methanol, solid-phase extraction, 
      derivatisation by the mixture of propionic acid anhydride and pyridine, and gas 
      chromatography/mass spectrometry (GC/MS). For amphetamine, methamphetamine, MDA, 
      MDMA, and MDEA analysis, hair samples were incubated in 1M sodium hydroxide, 
      extracted with ethyl acetate, derivatised with heptafluorobutyric acid anhydride 
      (HFBA), and assayed by GC/MS. The methods were reproducible (R.S.D. = 5.0-16.1%), 
      accurate (85.1-100.6%), and sensitive (LoD = 0.05-0.30ng/mg). The applied methods 
      confirmed consumption of heroin in 18 subjects based on positive 
      6-acetylmorphine. Among these 18 heroin consumers, methadone was found in four, 
      MDMA in two, and cocaine in two subjects. Cocaine only was present in two, 
      methadone only in two, methamphetamine only in two, and MDMA only in seven of the 
      36 subjects. In two out of nine coloured and bleached hair samples, no drug was 
      found. Despite the small number of subjects, this study has been able to indicate 
      the trend in drug abuse among young people in Croatia.
FAU - Skender, L
AU  - Skender L
AD  - Institute for Medical Research and Occupational Health, Clinical Toxicological 
      Chemistry Unit, Ksaverska c.2, P.O. Box 291, 10000, Zagreb, Croatia. 
      ljskender@imi.hr
FAU - Karacic, V
AU  - Karacic V
FAU - Brcic, I
AU  - Brcic I
FAU - Bagaric, A
AU  - Bagaric A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 (Amphetamines)
RN  - 0 (Narcotics)
RN  - UX6OWY2V7J (Codeine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amphetamines/*analysis
MH  - Codeine/*analysis
MH  - Female
MH  - Forensic Medicine
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Hair/*chemistry
MH  - Humans
MH  - Male
MH  - Narcotics/*analysis
EDAT- 2002/03/23 10:00
MHDA- 2002/06/05 10:01
CRDT- 2002/03/23 10:00
PHST- 2002/03/23 10:00 [pubmed]
PHST- 2002/06/05 10:01 [medline]
PHST- 2002/03/23 10:00 [entrez]
AID - S0379073801006302 [pii]
AID - 10.1016/s0379-0738(01)00630-2 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2002 Feb 18;125(2-3):120-6. doi: 10.1016/s0379-0738(01)00630-2.