PMID- 11911246
OWN - NLM
STAT- MEDLINE
DCOM- 20020419
LR  - 20121115
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 21
IP  - 6A
DP  - 2001 Nov-Dec
TI  - Antiviral, cytotoxic and apoptotic activities of picolinic acid on human 
      immunodeficiency virus-1 and human herpes simplex virus-2 infected cells.
PG  - 3773-6
AB  - The antiviral, cytotoxic and apoptotic effects of picolinic acid against human 
      immunodeficiency virus-1 (HIV-1) and human herpes simplex virus-2 (HSV-2) 
      infected cells were evaluated in cultured cells using in vitro assays. Picolinic 
      acid was tested at several concentrations (from 0.15 to 3 mM) against one input 
      dilution of the viruses to determine if the agent had any antiviral activity 
      against HIV-1 or HSV-2. The results showed that picolinic acid at 1.5 mM (185 
      ug/mL) and 3 mM (369 ug/mL) was active against HIV-1 and HSV-2-infected cells, 
      causing cytotoxicity which resulted in apoptosis and lack of viral replication. 
      In parallel control experiments with non-infected cells, picolinic acid also 
      caused cytotoxicity and apoptosis, which was more prominent at 3 mM than at 1.5 
      mM. Thus, infected cells appear to be slightly more sensitive to the cytotoxic 
      and apoptotic effects of picolinic acid. The overlapping of the antiviral profile 
      with the cytotoxic profile of picolinic acid indicates that, in vitro, the most 
      likely sequence of events is that picolinic acid initially causes cytotoxicity 
      which in turn results in apoptosis of cells infected with HIV-1 or HSV-2 and thus 
      reduces the amount of viral replication.
FAU - Fernandez-Pol, J A
AU  - Fernandez-Pol JA
AD  - Laboratory of Molecular Oncology, DVA Medical Center, St. Louis, MO 63106, USA. 
      fernandezpol@earthlink.net
FAU - Klos, D J
AU  - Klos DJ
FAU - Hamilton, P D
AU  - Hamilton PD
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Antiviral Agents)
RN  - 0 (Picolinic Acids)
RN  - QZV2W997JQ (picolinic acid)
SB  - IM
MH  - Anti-HIV Agents/*pharmacology/toxicity
MH  - Antiviral Agents/*pharmacology/toxicity
MH  - Apoptosis/drug effects
MH  - Cells, Cultured
MH  - HIV-1/*drug effects
MH  - Herpesvirus 2, Human/*drug effects
MH  - Humans
MH  - Microbial Sensitivity Tests
MH  - Picolinic Acids/*pharmacology/toxicity
MH  - Skin/cytology/drug effects/virology
MH  - Virus Replication/drug effects
EDAT- 2002/03/26 10:00
MHDA- 2002/04/20 10:01
CRDT- 2002/03/26 10:00
PHST- 2002/03/26 10:00 [pubmed]
PHST- 2002/04/20 10:01 [medline]
PHST- 2002/03/26 10:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2001 Nov-Dec;21(6A):3773-6.