PMID- 11911427
OWN - NLM
STAT- MEDLINE
DCOM- 20020813
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 42
IP  - 6
DP  - 2001 Nov-Dec
TI  - Isolated pentasomy of chromosome 8 in erythroleukemia.
PG  - 1409-12
AB  - Pentasomy 8 as a sole anomaly in hematological disorders is rare. Only 2 such 
      cases, one in acute monocytic leukemia and one in chronic myelomonocytic leukemia 
      have been described in the literature to date. Here, we report the first case of 
      a 42 year old man with erythroleukemia displaying a pentasomy 8 clone. 
      Conventional cytogenetics of bone marrow cells showed 16 metaphases with 
      pentasomy 8 and 9 with normal diploidy. Fluorescence in situ hybridization (FISH) 
      analysis using a whole chromosome painting probe and a centromeric probe specific 
      for chromosome 8 confirmed the presence of pentasomy 8 and also revealed a low 
      percentage of a trisomic and a tetrasomic clone. The patient died three days 
      after diagnosis without chemotherapy. The findings suggest that pentasomy 8 is 
      associated with a heterogeneous group of myeloid disorders and probably plays a 
      specific role in the progression of myeloid neoplasia.
FAU - Athanasiadou, A
AU  - Athanasiadou A
AD  - Department of Haematology, George Papanicolaou General Hospital, Thessaloniki, 
      Greece.
FAU - Saloum, R
AU  - Saloum R
FAU - Gaitatzi, M
AU  - Gaitatzi M
FAU - Anagnostopoulos, A
AU  - Anagnostopoulos A
FAU - Fassas, A
AU  - Fassas A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
SB  - IM
MH  - Adult
MH  - Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 8
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Erythroblastic, Acute/*genetics
MH  - Male
EDAT- 2002/03/26 10:00
MHDA- 2002/08/14 10:01
CRDT- 2002/03/26 10:00
PHST- 2002/03/26 10:00 [pubmed]
PHST- 2002/08/14 10:01 [medline]
PHST- 2002/03/26 10:00 [entrez]
AID - 10.3109/10428190109097771 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2001 Nov-Dec;42(6):1409-12. doi: 10.3109/10428190109097771.