PMID- 11913066 OWN - NLM STAT- MEDLINE DCOM- 20020404 LR - 20220318 IS - 1474-1733 (Print) IS - 1474-1733 (Linking) VI - 2 IP - 3 DP - 2002 Mar TI - Mouse and human dendritic cell subtypes. PG - 151-61 AB - Dendritic cells (DCs) collect and process antigens for presentation to T cells, but there are many variations on this basic theme. DCs differ in the regulatory signals they transmit, directing T cells to different types of immune response or to tolerance. Although many DC subtypes arise from separate developmental pathways, their development and function are modulated by exogenous factors. Therefore, we must study the dynamics of the DC network in response to microbial invasion. Despite the difficulty of comparing the DC systems of humans and mice, recent work has revealed much common ground. FAU - Shortman, Ken AU - Shortman K AD - Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia. shortman@wehi.edu.au FAU - Liu, Yong-Jun AU - Liu YJ LA - eng PT - Journal Article PT - Review PL - England TA - Nat Rev Immunol JT - Nature reviews. Immunology JID - 101124169 SB - IM MH - Animals MH - Antigen Presentation MH - Antigen-Presenting Cells/physiology MH - Dendritic Cells/*classification/physiology MH - Humans MH - Immune Tolerance MH - Mice MH - Stem Cells/physiology MH - T-Lymphocytes/immunology RF - 96 EDAT- 2002/03/27 10:00 MHDA- 2002/04/18 10:01 CRDT- 2002/03/27 10:00 PHST- 2002/03/27 10:00 [pubmed] PHST- 2002/04/18 10:01 [medline] PHST- 2002/03/27 10:00 [entrez] AID - 10.1038/nri746 [doi] PST - ppublish SO - Nat Rev Immunol. 2002 Mar;2(3):151-61. doi: 10.1038/nri746.