PMID- 11913712
OWN - NLM
STAT- MEDLINE
DCOM- 20020911
LR  - 20151119
IS  - 1078-0297 (Print)
IS  - 1078-0297 (Linking)
VI  - 108
IP  - 3-4
DP  - 2000
TI  - Metabolic changes in DOCA-salt hypertensive rats.
PG  - 201-11
AB  - In a previous report, we observed an altered proportion of fiber types and a 
      reduction of capillary per fiber ratio in extensor digitorus longus (EDL) and 
      soleus (SOL) muscles of deoxicorticosterone acetate (DOCA)-salt hypertensive rats 
      when compared with controls. The aim of the present study was to ascertain 
      various carbohydrate and lipid enzyme activities and substrates that may be 
      involved in the morphological changes reported. In the SOL muscle of hypertensive 
      rats, glucose, glycogen and triglycerides (TG) levels were increased, citrate 
      synthase (CS) and beta-hydroxy-acyl-CoA dehydrogenase (HAD) activities were 
      reduced, while hexokinase (HK) and lipoprotein lipase (LPL), LPL mass, lactate 
      and free fatty acids (FFA) levels were unchanged. In EDL muscles of hypertensive 
      rats, glycogen levels and LPL mass were higher than in controls, while CS, HAD, 
      HK, and LPL activities and glucose, lactate, FFA and TG levels were unmodified. 
      Serum levels of insulin, TG, cholesterol and FFA were increased while glucose 
      levels were decreased and high-density lipoprotein-cholesterol levels were 
      similar in hypertensive rats when compared with controls. In conclusion, 
      hypertensive rats showed increased glycogen in both EDL and SOL muscles, with 
      hyperinsulinemia and reduced glycemia. Hyperinsulinemia might have been a 
      compensatory response to insulin resistance. The oxidative capacity of SOL muscle 
      was reduced indicating that glucose uptake was conduced via non-oxidative 
      metabolism. TG, FFA and cholesterol were increased in serum and TG in SOL muscle.
FAU - Hernandez, N
AU  - Hernandez N
AD  - Institute of Experimental Medicine, Faculty of Medicine, Central University of 
      Venezuela, Caracas. hernandn@camelot.rect.ucv.ve
FAU - Torres, S H
AU  - Torres SH
FAU - De Sanctis, J B
AU  - De Sanctis JB
FAU - Sosa, A
AU  - Sosa A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Res Commun Mol Pathol Pharmacol
JT  - Research communications in molecular pathology and pharmacology
JID - 9437512
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 40GP35YQ49 (Desoxycorticosterone)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 9005-79-2 (Glycogen)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 1.1.1.- (3-Hydroxyacyl CoA Dehydrogenases)
RN  - EC 2.3.3.1 (Citrate (si)-Synthase)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 3.1.1.34 (Lipoprotein Lipase)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - 3-Hydroxyacyl CoA Dehydrogenases/metabolism
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Cholesterol/blood
MH  - Citrate (si)-Synthase/metabolism
MH  - Desoxycorticosterone/toxicity
MH  - Fatty Acids, Nonesterified/blood/metabolism
MH  - Glucose/metabolism
MH  - Glycogen/metabolism
MH  - Hexokinase/metabolism
MH  - Hypertension/blood/*chemically induced/*metabolism
MH  - Insulin/blood
MH  - Lactic Acid/metabolism
MH  - Lipoprotein Lipase/metabolism
MH  - Muscle, Skeletal/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sodium Chloride
MH  - Triglycerides/blood/metabolism
EDAT- 2002/03/27 10:00
MHDA- 2002/09/12 10:01
CRDT- 2002/03/27 10:00
PHST- 2002/03/27 10:00 [pubmed]
PHST- 2002/09/12 10:01 [medline]
PHST- 2002/03/27 10:00 [entrez]
PST - ppublish
SO  - Res Commun Mol Pathol Pharmacol. 2000;108(3-4):201-11.