PMID- 11914421
OWN - NLM
STAT- MEDLINE
DCOM- 20020522
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 58
IP  - 6
DP  - 2002 Mar 26
TI  - HLA-A2 homozygosity but not heterozygosity is associated with Alzheimer disease.
PG  - 973-5
AB  - AD is associated with the A2 allele of the human leukocyte antigen (HLA). 
      However, it is not currently known whether there is any difference between A2 
      homozygotes and A2 heterozygotes. The authors studied 458 patients with AD and 
      found that A2 homozygotes had earlier onset of AD than either A2 heterozygotes 
      (5.4 years, p = 0.002) or those without A2 (5.2 years, p = 0.003). The 
      "recessive" nature of this association suggests that loss of function at the 
      HLA-A locus or a closely linked gene is associated with AD.
FAU - Zareparsi, S
AU  - Zareparsi S
AD  - Department of Neurology, Oregon Health Sciences University, Portland 97201, USA. 
      zarepars@ohsu.edu
FAU - James, D M
AU  - James DM
FAU - Kaye, J A
AU  - Kaye JA
FAU - Bird, T D
AU  - Bird TD
FAU - Schellenberg, G D
AU  - Schellenberg GD
FAU - Payami, H
AU  - Payami H
LA  - eng
GR  - U24 AG021886/AG/NIA NIH HHS/United States
GR  - AG-08017/AG/NIA NIH HHS/United States
GR  - AG05136/AG/NIA NIH HHS/United States
GR  - P30 AG 10133/AG/NIA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (HLA-A2 Antigen)
SB  - IM
MH  - Age of Onset
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Alzheimer Disease/epidemiology/*genetics
MH  - Female
MH  - *Genetic Carrier Screening
MH  - HLA-A2 Antigen/*genetics
MH  - *Homozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2002/03/27 10:00
MHDA- 2002/05/25 10:01
CRDT- 2002/03/27 10:00
PHST- 2002/03/27 10:00 [pubmed]
PHST- 2002/05/25 10:01 [medline]
PHST- 2002/03/27 10:00 [entrez]
AID - 10.1212/wnl.58.6.973 [doi]
PST - ppublish
SO  - Neurology. 2002 Mar 26;58(6):973-5. doi: 10.1212/wnl.58.6.973.