PMID- 11914929
OWN - NLM
STAT- MEDLINE
DCOM- 20020521
LR  - 20161020
IS  - 1435-2443 (Print)
IS  - 1435-2443 (Linking)
VI  - 386
IP  - 8
DP  - 2002 Mar
TI  - Clinical and molecular diagnosis of multiple endocrine neoplasia type 1.
PG  - 547-52
AB  - Multiple endocrine neoplasia type 1 (MEN1) is a classic hereditary tumor syndrome 
      characterized by a genetic predisposition to develop a variety of neuroendocrine 
      neoplasias and hormone excess syndromes. The disease is caused by inactivating 
      mutations of the MEN1 tumor suppressor gene, detectable in >95% of MEN1 families. 
      The distinction of MEN1-associated tumors from sporadic neuroendocrine neoplasias 
      is clinically important for providing optimal surgical and medical therapy, 
      appropriate clinical follow-up, and counsel for affected patients and their 
      families. Since MEN1 gene analysis became available in 1997, new diagnostic 
      approaches have evolved in clinical management, to be reviewed in this article. 
      Genetic screening of MEN1 families will allow definition of individual disease 
      risk at a preclinical stage, thus helping to allocate medical resources and 
      treatment as individually needed. These new diagnostic approaches are expected to 
      reduce MEN1-associated morbidity and mortality, health care expenses, and 
      psychological disease burden.
FAU - Karges, Wolfram
AU  - Karges W
AD  - Division of Endocrinology, Department of Internal Medicine, University of Ulm, 
      Robert Koch Strasse, 89081 Ulm, Germany. wolfram.karges@medizin.uni-ulm.de
FAU - Schaaf, Ludwig
AU  - Schaaf L
FAU - Dralle, Henning
AU  - Dralle H
FAU - Boehm, Bernhard O
AU  - Boehm BO
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20020124
PL  - Germany
TA  - Langenbecks Arch Surg
JT  - Langenbeck's archives of surgery
JID - 9808285
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - DNA Mutational Analysis
MH  - Ethics
MH  - *Genes, Tumor Suppressor
MH  - *Genetic Testing/legislation & jurisprudence
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis/*genetics
MH  - Mutation
MH  - Neoplasm Proteins/*genetics
MH  - *Proto-Oncogene Proteins
RF  - 21
EDAT- 2002/03/27 10:00
MHDA- 2002/05/22 10:01
CRDT- 2002/03/27 10:00
PHST- 2001/10/11 00:00 [received]
PHST- 2001/11/26 00:00 [accepted]
PHST- 2002/03/27 10:00 [pubmed]
PHST- 2002/05/22 10:01 [medline]
PHST- 2002/03/27 10:00 [entrez]
AID - 10.1007/s00423-001-0268-4 [doi]
PST - ppublish
SO  - Langenbecks Arch Surg. 2002 Mar;386(8):547-52. doi: 10.1007/s00423-001-0268-4. 
      Epub 2002 Jan 24.