PMID- 11915784
OWN - NLM
STAT- MEDLINE
DCOM- 20020910
LR  - 20191105
IS  - 1526-484X (Print)
IS  - 1526-484X (Linking)
VI  - 11
IP  - 4
DP  - 2001 Dec
TI  - Pre-exercise carbohydrate status and immune responses to prolonged cycling: II. 
      Effect on plasma cytokine concentration.
PG  - 503-12
AB  - Ingesting carbohydrate (CHO) beverages during heavy exercise is associated with 
      smaller changes in the plasma concentrations of several cytokines. The influence 
      of dietary CHO availability on these responses has not been determined. 
      Therefore, the present study investigated the influence of pre-exercise CHO 
      status on plasma interleukin (IL)-6, IL-10, and IL-1 receptor antagonist (IL-1ra) 
      responses to prolonged cycling. Seven trained male cyclists performed a 
      glycogen-lowering bout of cycling and were randomly assigned to follow a diet 
      ensuring either greater than 70% (HIGH) or less than 10% (LOW) of daily energy 
      intake from CHO for the next 3 days. On day 4 subjects performed an exercise test 
      that comprised cycling for 1 hour at 60% Wmax immediately followed by a 
      time-trial (TT) ensuring an energy expenditure equivalent to cycling for 30 min 
      at 80% Wmax. Subjects repeated the protocol after 7 days, this time following the 
      second diet. The order of the trials was counterbalanced. At 1 and 2 hours 
      post-TT, plasma concentrations of IL-6 and IL-10 were 2-fold greater on the LOW 
      trial than on the HIGH trial, and peak plasma concentrations of IL-1ra were 
      9-fold greater on the LOW trial than on the HIGH trial. These findings suggest 
      that pre-exercise CHO status can influence the plasma cytokine response to 
      prolonged cycling.
FAU - Bishop, N C
AU  - Bishop NC
AD  - Department of Physical Education, Sports Science and Recreation Management at 
      Loughborough University, UK.
FAU - Walsh, N P
AU  - Walsh NP
FAU - Haines, D L
AU  - Haines DL
FAU - Richards, E E
AU  - Richards EE
FAU - Gleeson, M
AU  - Gleeson M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Int J Sport Nutr Exerc Metab
JT  - International journal of sport nutrition and exercise metabolism
JID - 100939812
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Interleukin-6)
RN  - 0 (Receptors, Interleukin-1)
RN  - 130068-27-8 (Interleukin-10)
RN  - 9005-79-2 (Glycogen)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Beverages
MH  - Bicycling/*physiology
MH  - Blood Glucose/analysis/immunology
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Glycogen/metabolism
MH  - Humans
MH  - Hydrocortisone/blood/immunology
MH  - Interleukin-10/*blood/immunology
MH  - Interleukin-6/*blood/immunology
MH  - Kinetics
MH  - Male
MH  - Nutritional Status
MH  - Receptors, Interleukin-1/*antagonists & inhibitors/immunology
EDAT- 2002/03/28 10:00
MHDA- 2002/09/11 10:01
CRDT- 2002/03/28 10:00
PHST- 2002/03/28 10:00 [pubmed]
PHST- 2002/09/11 10:01 [medline]
PHST- 2002/03/28 10:00 [entrez]
AID - 10.1123/ijsnem.11.4.503 [doi]
PST - ppublish
SO  - Int J Sport Nutr Exerc Metab. 2001 Dec;11(4):503-12. doi: 
      10.1123/ijsnem.11.4.503.