PMID- 11917281
OWN - NLM
STAT- MEDLINE
DCOM- 20020418
LR  - 20240109
IS  - 1053-4296 (Print)
IS  - 1053-4296 (Linking)
VI  - 12
IP  - 1 Suppl 1
DP  - 2002 Jan
TI  - Radiation pneumonitis and early circulatory cytokine markers.
PG  - 26-33
AB  - Radiation pneumonitis is a distinct clinical entity that differs from other 
      pulmonary symptoms such as allergic pneumonitis, chemical pneumonitis, or 
      pneumonia by various infectious agents. Recent research has supported the 
      mechanism of cellular interaction between lung parenchymal cells and circulating 
      immune cells mediated through a variety of cytokines including proinflammatory 
      cytokines, chemokines, adhesion molecules, and profibrotic cytokines. Identifying 
      reliable biomarkers for radiation pneumonitis will allow us to identify 
      individuals at risk for pneumonitis before or during the early stage of therapy. 
      Prospective blood sampling, scoring of respiratory symptoms, and chest imaging 
      were conducted for patients receiving thoracic radiotherapy for malignancy. 
      Serial plasma specimens were analyzed for circulating cytokine changes before, 
      during, and up to 12 weeks after radiation. Radiation pneumonitis was diagnosed 
      using National Cancer Institute (NCI) common toxicity criteria. Cytokine analysis 
      was assayed for interleukin 1alpha (IL-1alpha), interleukin 6 (IL-6), monocyte 
      chemotactic protein 1 (MCP-1), E-selectin, L-selectin, transforming growth factor 
      beta1 (TGF-beta1), and basic fibroblast growth factor (bFGF) using enzyme linked 
      immmunosorbant assay (ELISA). Twenty-four patients had clinical follow-up longer 
      than 12 months after radiotherapy. Thirteen had symptomatic pneumonitis (NCI 
      grade 2). The peak incidence of symptoms was between 6 and 13 weeks after 
      radiotherapy. Six patients had only radiographic infiltrates (NCI grade 1). Five 
      patients did not have clinical or radiographic pneumonitis. Both IL-1alpha and 
      IL-6 levels were significantly higher before, during, and after radiotherapy for 
      those who had pneumonitis. The pattern of changes of MCP-1, E-selectin, 
      L-selectin, TGF-beta1, and bFGF varied, but none of these cytokines correlated 
      with radiation pneumonitis. Analysis of a panel of circulating cytokines with 
      different putative functions in radiation pulmonary injury identified IL-1alpha 
      and IL-6 as early circulating cytokine markers for radiation pneumonitis.
CI  - Copyright 2002, Elsevier Science (USA). All rights reserved.
FAU - Chen, Yuhchyau
AU  - Chen Y
AD  - Department of Radiation Oncology, James P. Wilmot Cancer Center, University of 
      Rochester, Rochester, NY 14642, USA.
FAU - Williams, Jacqueline
AU  - Williams J
FAU - Ding, Ivan
AU  - Ding I
FAU - Hernady, Eric
AU  - Hernady E
FAU - Liu, Weimin
AU  - Liu W
FAU - Smudzin, Therese
AU  - Smudzin T
FAU - Finkelstein, Jacob N
AU  - Finkelstein JN
FAU - Rubin, Philip
AU  - Rubin P
FAU - Okunieff, Paul
AU  - Okunieff P
LA  - eng
GR  - P-01 CA11051-26/CA/NCI NIH HHS/United States
GR  - R-01 CA27791-15/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Semin Radiat Oncol
JT  - Seminars in radiation oncology
JID - 9202882
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Cytokines/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Interleukin-1/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - Radiation Pneumonitis/blood/*diagnosis
MH  - Risk Factors
MH  - Thoracic Neoplasms/*radiotherapy
EDAT- 2002/03/28 10:00
MHDA- 2002/04/19 10:01
CRDT- 2002/03/28 10:00
PHST- 2002/03/28 10:00 [pubmed]
PHST- 2002/04/19 10:01 [medline]
PHST- 2002/03/28 10:00 [entrez]
AID - asrao012b00s26 [pii]
AID - 10.1053/srao.2002.31360 [doi]
PST - ppublish
SO  - Semin Radiat Oncol. 2002 Jan;12(1 Suppl 1):26-33. doi: 10.1053/srao.2002.31360.