PMID- 11918695
OWN - NLM
STAT- MEDLINE
DCOM- 20020419
LR  - 20190513
IS  - 0019-2805 (Print)
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Linking)
VI  - 105
IP  - 3
DP  - 2002 Mar
TI  - Mycobacterial infection inhibits established allergic inflammatory responses via 
      alteration of cytokine production and vascular cell adhesion molecule-1 
      expression.
PG  - 336-43
AB  - Our previous studies, as well as those of others, have demonstrated that local or 
      systemic Mycobacterium bovis bacille Calmette-Guerin (BCG) infection can inhibit 
      de novo allergen-induced asthma-like reactions, but the effect of this infection 
      on established allergic responses is unknown. The aim of this study was therefore 
      to examine the effect of mycobacterial infection on established allergy in a 
      murine model of asthma-like reaction. Mice were sensitized with ovalbumin (OVA) 
      in alum followed by infection with BCG and subsequent intranasal challenge with 
      the same allergen. In some experiments, mice were sensitized with OVA followed by 
      intranasal challenge with OVA and then given BCG infection with subsequent 
      rechallenge with OVA. Mice without BCG infection but treated with OVA in the same 
      manner, were used as a control. The mice were examined for immunoglobulin E (IgE) 
      response and eosinophilic inflammation, mucus production, cytokine/chemokine 
      patterns and adhesion molecule expression in the lung. The results showed that 
      postallergen BCG infection suppressed the established airway eosinophilia and 
      mucus overproduction, but not IgE responses. The inhibition of asthma-like 
      reactions by BCG infection was correlated with a shift of allergen-driven 
      cytokine production pattern and, more interestingly, with a dramatic decrease of 
      vascular cell adhesion molecule-1 (VCAM-1) expression in the lung. These findings 
      suggest that intracellular bacterial infection can inhibit established allergic 
      responses via alteration of local cytokine production and the expression of 
      adhesion molecules.
FAU - Yang, Xi
AU  - Yang X
AD  - Immune Regulation of Allergy Research Group, Department of Medical Microbiology, 
      Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. 
      yangxi@cc.umanitoba.ca
FAU - Fan, Yijun
AU  - Fan Y
FAU - Wang, Shuhe
AU  - Wang S
FAU - Han, Xiaobing
AU  - Han X
FAU - Yang, Jie
AU  - Yang J
FAU - Bilenki, Laura
AU  - Bilenki L
FAU - Chen, Lijun
AU  - Chen L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Antigens)
RN  - 0 (Cytokines)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Antigens/immunology
MH  - Asthma/complications/*immunology
MH  - Cytokines/*biosynthesis
MH  - Endothelium, Vascular/immunology
MH  - Female
MH  - *Immune Tolerance
MH  - Immunoglobulin E/biosynthesis
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mucus/immunology
MH  - Mycobacterium Infections/complications/*immunology
MH  - *Mycobacterium bovis
MH  - Ovalbumin/immunology
MH  - Pulmonary Eosinophilia/complications/immunology
MH  - Th2 Cells/immunology
MH  - Vascular Cell Adhesion Molecule-1/metabolism
PMC - PMC1782668
EDAT- 2002/03/29 10:00
MHDA- 2002/04/20 10:01
PMCR- 2003/03/01
CRDT- 2002/03/29 10:00
PHST- 2002/03/29 10:00 [pubmed]
PHST- 2002/04/20 10:01 [medline]
PHST- 2002/03/29 10:00 [entrez]
PHST- 2003/03/01 00:00 [pmc-release]
AID - 10.1046/j.0019-2805.2002.01377.x [doi]
PST - ppublish
SO  - Immunology. 2002 Mar;105(3):336-43. doi: 10.1046/j.0019-2805.2002.01377.x.