PMID- 11919402
OWN - NLM
STAT- MEDLINE
DCOM- 20020606
LR  - 20171101
IS  - 0250-8095 (Print)
IS  - 0250-8095 (Linking)
VI  - 22
IP  - 1
DP  - 2002 Jan-Feb
TI  - Correlation between soluble markers of endothelial dysfunction in patients with 
      renal failure.
PG  - 42-7
AB  - AIM: Damage to the endothelium is an important component of atherosclerosis. It 
      has been suggested to be quantified by measuring plasma markers, such as von 
      Willebrand factor and thrombomodulin and soluble adhesion molecules. We 
      hypothesized there may exist a correlation between the plasma levels of von 
      Willebrand factor and thrombomodulin as markers of endothelial cell dysfunction 
      and the serum concentrations of soluble adhesion molecules and monocyte 
      chemoattractant protein-1 (MCP-1) in patients with renal insufficiency, and in 
      patients on peritoneal dialysis or hemodialysis since these three groups of 
      kidney patients are highly prone to develop cardiovascular diseases. RESULTS: The 
      concentrations of von Willebrand factor and thrombomodulin in plasma were 
      significantly higher in patients with kidney diseases as compared to healthy 
      subjects (p = 0.017 and p < 0.001, respectively). The patients also had 
      significantly higher concentrations of soluble vascular cell adhesion molecule-1 
      (sVCAM-1) and MCP-1 compared to healthy controls (p < 0.001 for both 
      comparisons). There were strong correlations between the concentration of soluble 
      intercellular adhesion molecule-1 (sICAM-1) and von Willebrand factor in patients 
      with kidney failure (r = 0.63, p < 0.001) and between the concentration of 
      thrombomodulin and sVCAM-1 (r = 0.61, p < 0.001). Furthermore, a negative 
      correlation was observed between the concentration of thrombomodulin and the cell 
      surface expression of CD11b on monocytes and granulocytes in the peripheral 
      circulation (p < 0.01 in both cases). CONCLUSION: The strong correlation between 
      markers of endothelial dysfunction and soluble adhesion molecules in patients 
      with renal insufficiency and on dialysis strengthen the view that an ongoing 
      stress on endothelial cells is present in this group of patients. This may play a 
      pathophysiological role in the development of cardiovascular disease.
CI  - Copyright 2002 S. Karger AG, Basel
FAU - Jacobson, Stefan H
AU  - Jacobson SH
AD  - Department of Medicine, Division of Nephrology, Karolinska Hospital and 
      Karolinska Institute, Stockholm, Sweden. stefan.jacobson@ks.se
FAU - Egberg, Nils
AU  - Egberg N
FAU - Hylander, Britta
AU  - Hylander B
FAU - Lundahl, Joachim
AU  - Lundahl J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Am J Nephrol
JT  - American journal of nephrology
JID - 8109361
RN  - 0 (Thrombomodulin)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 0 (von Willebrand Factor)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Aged
MH  - Arteriosclerosis/*blood
MH  - Endothelium, Vascular/*pathology/physiopathology
MH  - Humans
MH  - Inflammation
MH  - Intercellular Adhesion Molecule-1/blood
MH  - Kidney Failure, Chronic/*blood
MH  - Male
MH  - Middle Aged
MH  - Renal Dialysis
MH  - Thrombomodulin/*blood
MH  - Vascular Cell Adhesion Molecule-1/blood
MH  - von Willebrand Factor/*analysis
EDAT- 2002/03/29 10:00
MHDA- 2002/06/12 10:01
CRDT- 2002/03/29 10:00
PHST- 2002/03/29 10:00 [pubmed]
PHST- 2002/06/12 10:01 [medline]
PHST- 2002/03/29 10:00 [entrez]
AID - 46673 [pii]
AID - 10.1159/000046673 [doi]
PST - ppublish
SO  - Am J Nephrol. 2002 Jan-Feb;22(1):42-7. doi: 10.1159/000046673.