PMID- 11923422
OWN - NLM
STAT- MEDLINE
DCOM- 20020408
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 22
IP  - 7
DP  - 2002 Apr 1
TI  - Failure of brain-derived neurotrophic factor-dependent neuron survival in mouse 
      trisomy 16.
PG  - 2571-8
AB  - The neurotrophin, brain derived neurotrophic factor (BDNF), exerts multiple 
      effects on the development and maintenance of the nervous system, including 
      regulating synaptic plasticity and promoting neuron survival. Here we report the 
      selective failure of BDNF-dependent survival in cultured hippocampal neurons from 
      the trisomy 16 (Ts16) mouse, an animal model of Down syndrome. This failure is 
      accompanied by overexpression of a truncated, kinase-deficient isoform (T1) of 
      the BDNF receptor tyrosine receptor kinase B (trkB). Adenovirus-mediated 
      introduction of exogenous full-length trkB into Ts16 neurons fully restored 
      BDNF-dependent survival, whereas exogenous truncated trkB expression in normal, 
      euploid neurons reproduced the Ts16 BDNF signaling failure. Thus, the failure of 
      Ts16 neurons to respond to BDNF is caused by dysregulation of trkB isoform 
      expression. Such a neurotrophin signaling defect could contribute to 
      developmental and degenerative disorders of the nervous system.
FAU - Dorsey, Susan G
AU  - Dorsey SG
AD  - Department of Physiology, University of Maryland School of Medicine, Baltimore, 
      Maryland 21201, USA.
FAU - Bambrick, Linda L
AU  - Bambrick LL
FAU - Balice-Gordon, Rita J
AU  - Balice-Gordon RJ
FAU - Krueger, Bruce K
AU  - Krueger BK
LA  - eng
GR  - F31NR07189/NR/NINR NIH HHS/United States
GR  - AG10686/AG/NIA NIH HHS/United States
GR  - F31 NR007189/NR/NINR NIH HHS/United States
GR  - NS34373/NS/NINDS NIH HHS/United States
GR  - R01 NS040492/NS/NINDS NIH HHS/United States
GR  - AG15207/AG/NIA NIH HHS/United States
GR  - NS40492/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Protein Isoforms)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (Receptor, trkC)
SB  - IM
EIN - J Neurosci 2002 May 1;22(9):following Table of Contents
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*metabolism/pharmacology
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Disease Models, Animal
MH  - Down Syndrome/genetics/metabolism
MH  - Immunohistochemistry
MH  - Mice
MH  - Neurons/cytology/drug effects/*metabolism
MH  - Phosphorylation/drug effects
MH  - Protein Isoforms/metabolism
MH  - Receptor, trkB/metabolism
MH  - Receptor, trkC/biosynthesis
MH  - Signal Transduction/drug effects
MH  - Trisomy/*physiopathology
PMC - PMC6758291
EDAT- 2002/03/30 10:00
MHDA- 2002/04/12 10:01
PMCR- 2002/10/01
CRDT- 2002/03/30 10:00
PHST- 2002/03/30 10:00 [pubmed]
PHST- 2002/04/12 10:01 [medline]
PHST- 2002/03/30 10:00 [entrez]
PHST- 2002/10/01 00:00 [pmc-release]
AID - 22/7/2571 [pii]
AID - 6265 [pii]
AID - 10.1523/JNEUROSCI.22-07-02571.2002 [doi]
PST - ppublish
SO  - J Neurosci. 2002 Apr 1;22(7):2571-8. doi: 10.1523/JNEUROSCI.22-07-02571.2002.