PMID- 11927139
OWN - NLM
STAT- MEDLINE
DCOM- 20020619
LR  - 20220408
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 109
IP  - 2
DP  - 2002 Mar 15
TI  - Decreased serum brain-derived neurotrophic factor levels in major depressed 
      patients.
PG  - 143-8
AB  - Recent findings with animal models have suggested a possible role for 
      brain-derived neurotrophic factor (BDNF) in depression. We have therefore 
      hypothesized that depression could be characterized by low levels of serum BDNF. 
      Major depressed patients (15F + 15M) diagnosed according to DSM-IV criteria and 
      healthy controls (15F + 15M) participated in the study. Serum BDNF was assayed 
      with the ELISA method and the severity of depression was evaluated with 
      Montgomery-Asberg-Depression Rating Scale (MADRS). BDNF levels were significantly 
      lower in patients than in controls: 22.6 +/- 3 and 26.5 +/- 7 ng/ml (t-test = 
      2.7; d.f. = 58; P < 0.01). They were negatively correlated to the MADRS scores (r 
      = -0.55; P < 0.02). Female patients were more depressed and released less BDNF 
      than men. Analysis of covariance (MADRS and gender as independent variable vs. 
      BDNF as dependent variable) indicated that depression severity mainly accounted 
      for the negative correlation. These results suggest that major depression is 
      characterized by low serum BDNF levels and support the hypothesis of neurotrophic 
      factor involvement in affective disorders.
FAU - Karege, Felicien
AU  - Karege F
AD  - Laboratory of Biochemistry, Division of Neuropsychiatry, Geneva University 
      Hospitals, 2 chemin du Petit Bel-Air, CH-1225 Chene-Bourg, Switzerland. 
      karege@biolo.unige.ch
FAU - Perret, Guillaume
AU  - Perret G
FAU - Bondolfi, Guido
AU  - Bondolfi G
FAU - Schwald, Michele
AU  - Schwald M
FAU - Bertschy, Gilles
AU  - Bertschy G
FAU - Aubry, Jean-Michel
AU  - Aubry JM
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Blood Platelets/metabolism
MH  - Brain/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/blood/diagnosis/*physiopathology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Reference Values
MH  - Sex Factors
EDAT- 2002/04/03 10:00
MHDA- 2002/06/20 10:01
CRDT- 2002/04/03 10:00
PHST- 2002/04/03 10:00 [pubmed]
PHST- 2002/06/20 10:01 [medline]
PHST- 2002/04/03 10:00 [entrez]
AID - S0165178102000057 [pii]
AID - 10.1016/s0165-1781(02)00005-7 [doi]
PST - ppublish
SO  - Psychiatry Res. 2002 Mar 15;109(2):143-8. doi: 10.1016/s0165-1781(02)00005-7.