PMID- 11928230
OWN - NLM
STAT- MEDLINE
DCOM- 20021030
LR  - 20061115
IS  - 0377-8231 (Print)
IS  - 0377-8231 (Linking)
VI  - 156
IP  - 5-6
DP  - 2001
TI  - [Stromelysin-1 in inflammatory disease: significance, specificity, and regulation 
      elements].
PG  - 275-81; discussion 281-3
AB  - Stromelysin-1 or matrix metalloproteinase-3 (MMP-3) is a key enzyme of the 
      degradation of the extracellular matrix in rheumatoid arthritis. MMP-3 is indeed 
      induced by pro-inflammatory cytokines and may in turn activate other 
      metalloproteinases. MMP-3 is a synovial parameter reflecting the local 
      inflammatory reaction induced by inflammatory cytokines. It is not specific for 
      rheumatoid arthritis nor for the erosive capacity of an arthropathy, which does 
      not exclude its role in articular degradation. Serum MMP-3 is increased in 
      diseases characterized by synovitis but also by steroid therapy. Although it is 
      not disease-specific, serum MMP-3 could be useful as a synovial-derived marker of 
      local inflammation in rheumatoid arthritis, in parallel to CRP which is a 
      systemic marker of inflammation. Furthermore, early determination of serum MMP-3 
      could constitute a new tool predictive of the disease activity and the 
      therapeutic response in rheumatoid arthritis.
FAU - Ribbens, C
AU  - Ribbens C
AD  - Universite de Liege, Centre hospitalier universitaire du Sart-Tilman, Service de 
      Rhumatologie, Centre d'Etude des Maladies inflammatoires chroniques.
FAU - Malaise, M
AU  - Malaise M
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - La stromelysine-1 en pathologie inflammatoire: signification, specificite et 
      elements de regulation.
PL  - Belgium
TA  - Bull Mem Acad R Med Belg
JT  - Bulletin et memoires de l'Academie royale de medecine de Belgique
JID - 7608462
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Arthritis, Rheumatoid/*enzymology
MH  - Humans
MH  - Matrix Metalloproteinase 3/analysis/*physiology
MH  - Organ Specificity
MH  - Synovial Fluid/chemistry/physiology
EDAT- 2002/04/04 10:00
MHDA- 2002/11/01 04:00
CRDT- 2002/04/04 10:00
PHST- 2002/04/04 10:00 [pubmed]
PHST- 2002/11/01 04:00 [medline]
PHST- 2002/04/04 10:00 [entrez]
PST - ppublish
SO  - Bull Mem Acad R Med Belg. 2001;156(5-6):275-81; discussion 281-3.