PMID- 11928894
OWN - NLM
STAT- MEDLINE
DCOM- 20020507
LR  - 20161021
IS  - 1641-4640 (Print)
IS  - 1509-572X (Linking)
VI  - 39
IP  - 4
DP  - 2001
TI  - Quantitative evaluation of intranuclear inclusions in SSPE: correlation with 
      disease duration.
PG  - 237-41
AB  - Three types of intranuclear inclusions in neurones, oligodendrocytes and 
      astrocytes were quantitatively evaluated by electron microscopy in the autopsy 
      material derived from six cases of subacute sclerosing panencephalitis (SSPE) 
      with different duration of disease. Viral nucleocapsids were found in neurones 
      and oligodendrocytes with the highest incidence (about 38% of nuclei) in two 
      acute cases (adolescent), whereas in two subacute cases only 10% of nuclei of 
      these cells contained nucleocapsids. However, in one acute case (child) and one 
      chronic case, no nucleocapsids were detected at all, despite very intensive 
      study. Two other types of intranuclear inclusions--nuclear bodies (NBs) and 
      granulofilamentous inclusions (GFs) were present in astrocytic nuclei in all 
      cases. Nuclear bodies were found the most frequently (about 66%) in cases of a 
      several-week-long duration, and their incidence decreased with the extended 
      duration of the disease. In the case of a seven-year-long duration, about 31% of 
      nuclei contained NBs. The incidence of certain types of NBs varied also in 
      individual groups of cases, and the same applied to the occurrence of cellular 
      nuclei with different numbers of NBs. Nuclear bodies types IVand V occurred with 
      similar frequency, regardless of the disease duration. The highest incidence of 
      nucleocapsids and NBs was accompanied by the highest (about 25%) frequency of GF 
      in astrocytic nuclei. The incidence of the latter declined with the prolonged 
      duration of the disease, and in the chronic case it was about 16 times lower than 
      in acute cases. In some acute and subacute cases, GF occurred together with NBs. 
      Astrocytic nuclei with both types of inclusions occurred with a similar frequency 
      (about 1.6-1.8%).
FAU - Lewandowska, E
AU  - Lewandowska E
AD  - Department of Neuropathology, Institute of Psychiatry and Neurology, Warszawa, 
      Poland. lewandow@ipin.edu.pl
FAU - Lechowicz, W
AU  - Lechowicz W
FAU - Szpak, G M
AU  - Szpak GM
FAU - Sobczyk, W
AU  - Sobczyk W
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Folia Neuropathol
JT  - Folia neuropathologica
JID - 9437431
SB  - IM
MH  - Adolescent
MH  - Astrocytes/pathology
MH  - Brain/pathology
MH  - Cell Nucleus/*pathology/ultrastructure
MH  - Child
MH  - Humans
MH  - Incidence
MH  - Inclusion Bodies/pathology
MH  - Measles virus/isolation & purification
MH  - Neurons/pathology
MH  - Nucleocapsid/ultrastructure
MH  - Oligodendroglia/pathology
MH  - Subacute Sclerosing Panencephalitis/epidemiology/*pathology/virology
EDAT- 2002/04/04 10:00
MHDA- 2002/05/08 10:01
CRDT- 2002/04/04 10:00
PHST- 2002/04/04 10:00 [pubmed]
PHST- 2002/05/08 10:01 [medline]
PHST- 2002/04/04 10:00 [entrez]
PST - ppublish
SO  - Folia Neuropathol. 2001;39(4):237-41.