PMID- 11929421
OWN - NLM
STAT- MEDLINE
DCOM- 20020510
LR  - 20190822
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 57
IP  - 2
DP  - 2002 Feb
TI  - Lack of association between atopic eczema/dermatitis syndrome and polymorphisms 
      in the promoter region of RANTES and regulatory region of MCP-1.
PG  - 160-3
AB  - BACKGROUND: Chemokines play an important role in the pathophysiology of atopic 
      eczema/dermatitis syndrome (AEDS) and allergy. Recently polymorphisms in the 
      promoter region of RANTES (regulated on activation normal T cell expressed and 
      secreted) and in the gene regulatory region of MCP-1 (monocyte chemoattractant 
      protein-1) have been found, which increase the expression of these chemokines. 
      The - 403A allele of the RANTES promoter region was found associated with AEDS in 
      German children. We investigated whether the presence of these polymorphisms was 
      associated with AEDS or allergy in Hungarian children. METHODS: One hundred and 
      twenty-eight children with AEDS, 102 allergic children without AEDS and 303 
      children of comparable ages without allergic disorders were screened for genotype 
      with a PCR-based assay. RESULTS: There were no significant differences in the 
      frequency of these polymorphisms, or in the distribution of genotypes between the 
      groups. The total IgE concentration, the white blood cell count and the blood 
      eosinophil cell count did not differ between the genotypes. CONCLUSION: In this 
      cohort of Hungarian children there was no association between - 28G, and - 403A 
      alleles in the RANTES promoter, - 2518G polymorphism in the distal regulatory 
      region of the MCP-1 and AEDS, or allergy.
FAU - Kozma, G T
AU  - Kozma GT
AD  - Department of Genetics, Cell- and Immunobiology, Semmelweis University Budapest, 
      Budapest, Hungary.
FAU - Falus, A
AU  - Falus A
FAU - Bojszko, A
AU  - Bojszko A
FAU - Krikovszky, D
AU  - Krikovszky D
FAU - Szabo, T
AU  - Szabo T
FAU - Nagy, A
AU  - Nagy A
FAU - Szalai, C
AU  - Szalai C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Chemokine CCL2/*genetics
MH  - Chemokine CCL5/*genetics
MH  - Child
MH  - Child Welfare
MH  - Child, Preschool
MH  - Dermatitis, Atopic/blood/ethnology/*genetics
MH  - Eosinophils
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genotype
MH  - Germany/epidemiology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Leukocyte Count
MH  - Male
MH  - Polymorphism, Genetic/*genetics
MH  - Prevalence
MH  - Promoter Regions, Genetic/*genetics
MH  - Regulatory Sequences, Nucleic Acid/*genetics
MH  - Statistics as Topic
EDAT- 2002/04/04 10:00
MHDA- 2002/05/11 10:01
CRDT- 2002/04/04 10:00
PHST- 2002/04/04 10:00 [pubmed]
PHST- 2002/05/11 10:01 [medline]
PHST- 2002/04/04 10:00 [entrez]
AID - 10.1034/j.1398-9995.2002.1s3361.x [doi]
PST - ppublish
SO  - Allergy. 2002 Feb;57(2):160-3. doi: 10.1034/j.1398-9995.2002.1s3361.x.