PMID- 11931709
OWN - NLM
STAT- MEDLINE
DCOM- 20030916
LR  - 20100323
IS  - 1671-4083 (Print)
IS  - 1671-4083 (Linking)
VI  - 23
IP  - 4
DP  - 2002 Apr
TI  - Reduction in monocyte chemoattractant protein-1 mRNA expression in peripheral 
      blood mononuclear cells of diamorphine addicts.
PG  - 336-8
AB  - AIM: To investigate whether there is a significant difference in the monocyte 
      chemoattractant protein-1 (MCP-1) mRNA expression between diamorphine ( heroin) 
      addicts and normal volunteers. METHODS: Expression of MCP-1 mRNA in the 
      peripheral blood mononuclear cells of diamorphine addicts and normal volunteers 
      was examine d by reverse transcription-polymerase chain reaction (RT-PCR) with 
      beta -actin as a n internal standard. Sequencing of RT-PCR products was performed 
      to confirm the specificity of these products in MCP-1 gene composition. RESULTS: 
      The relative M CP-1 mRNA expression ratios (MCP-1/beta-actin) in the peripheral 
      blood mononuclear cells of normal volunteers control group and diamorphine 
      addicts group were 0.47 +/- 0.12 (n = 15) and 0.21 +/- 0.09 (n =2 1), 
      respectively, and there was a significant difference (P < 0.05). CONCLUSION: The 
      significant reduction of MCP-1 mRNA expression in the peripheral blood 
      mononuclear cells of diamorphine addicts may be one of the mechanisms for the 
      high incidence o f severe infectious diseases, including AIDS, among diamorphine 
      addicts.
FAU - Song, Lie-Chang
AU  - Song LC
AD  - Laboratory for Molecular Pharmacology, Department of Hygiene, First Mi litary 
      Medical University, Guangzhou 510515, China. songlc@fimmu.edu.cn
FAU - Song, Chang
AU  - Song C
FAU - Zeng, Jun
AU  - Zeng J
FAU - Xiong, Miao-Lin
AU  - Xiong ML
FAU - Lou, Ning
AU  - Lou N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acta Pharmacol Sin
JT  - Acta pharmacologica Sinica
JID - 100956087
RN  - 0 (Actins)
RN  - 0 (Chemokine CCL2)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome
MH  - Actins/metabolism
MH  - Adult
MH  - Chemokine CCL2/genetics/*metabolism
MH  - Disease Susceptibility
MH  - Female
MH  - Heroin Dependence/*blood
MH  - Humans
MH  - Leukocytes, Mononuclear/*metabolism
MH  - Male
MH  - RNA, Messenger/genetics/metabolism
EDAT- 2002/04/05 10:00
MHDA- 2003/09/17 05:00
CRDT- 2002/04/05 10:00
PHST- 2002/04/05 10:00 [pubmed]
PHST- 2003/09/17 05:00 [medline]
PHST- 2002/04/05 10:00 [entrez]
PST - ppublish
SO  - Acta Pharmacol Sin. 2002 Apr;23(4):336-8.