PMID- 11931854
OWN - NLM
STAT- MEDLINE
DCOM- 20020712
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 933
IP  - 2
DP  - 2002 Apr 19
TI  - Involvement of brain cytokines in the neurobehavioral disturbances induced by 
      HIV-1 glycoprotein120.
PG  - 98-108
AB  - Intracerebroventricular (i.c.v.) administration of HIV-1 glycoprotein 120 
      (gp120), the envelope protein used by the virus to gain access into immune cells, 
      induces neurobehavioral alterations in rats. To examine the role of 
      proinflammatory cytokines in mediating these effects, we measured the effects of 
      gp120 on brain proinflammatory cytokine expression and the effects of 
      anti-inflammatory agents, including interleukin-1 receptor antagonist (IL-1ra), 
      pentoxifylline (a TNFalpha synthesis blocker) and IL-10, on gp120-induced 
      sickness behavior. I.c.v. administration of gp120 induced the expression of 
      IL-1beta, but not TNFalpha, mRNA in the hypothalamus, 3 h after the injection. 
      Pretreatment of rats with IL-1ra, but not with pentoxifylline, significantly 
      attenuated gp120-induced anorexia and loss in body weight, whereas both agents 
      had no effect on gp120-induced reduction in locomotor activity in the open field. 
      Pretreatment with either IL-1ra and pentoxifylline simultaneously, or with IL-10, 
      produced effects that were similar to the effects of IL-1ra alone. Together, 
      these findings indicate that IL-1, but not TNFalpha, mediates some of the 
      behavioral effects of acute gp120 administration, suggesting that brain IL-1 may 
      be involved in some of the neurobehavioral abnormalities evident in AIDS 
      patients.
FAU - Barak, Ohr
AU  - Barak O
AD  - Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, 
      Jerusalem, 91905, Israel.
FAU - Goshen, Inbal
AU  - Goshen I
FAU - Ben-Hur, Tamir
AU  - Ben-Hur T
FAU - Weidenfeld, Joseph
AU  - Weidenfeld J
FAU - Taylor, Anna N
AU  - Taylor AN
FAU - Yirmiya, Raz
AU  - Yirmiya R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Cytokines)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (HIV Envelope Protein gp120)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Interleukin-1)
RN  - 0 (RNA, Messenger)
RN  - 0 (Sialoglycoproteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - SD6QCT3TSU (Pentoxifylline)
SB  - IM
MH  - AIDS Dementia Complex/*immunology/metabolism/virology
MH  - Animals
MH  - Behavior, Animal/drug effects/*physiology
MH  - Brain/drug effects/*immunology/virology
MH  - Cytokines/drug effects/*immunology/metabolism
MH  - Drug Interactions/physiology
MH  - Enzyme Inhibitors/pharmacology
MH  - Gene Expression Regulation, Viral/drug effects/physiology
MH  - HIV Envelope Protein gp120/*immunology/metabolism/pharmacology
MH  - Injections, Intraventricular
MH  - Interleukin 1 Receptor Antagonist Protein
MH  - Interleukin-1/antagonists & inhibitors/genetics
MH  - Interleukin-10/pharmacology
MH  - Male
MH  - Nerve Degeneration/*immunology/metabolism/virology
MH  - Neurons/drug effects/*immunology/virology
MH  - Pentoxifylline/pharmacology
MH  - RNA, Messenger/drug effects/metabolism
MH  - Rats
MH  - Rats, Inbred F344
MH  - Sialoglycoproteins/immunology/pharmacology
MH  - Sick Role
MH  - Tumor Necrosis Factor-alpha/genetics
EDAT- 2002/04/05 10:00
MHDA- 2002/07/13 10:01
CRDT- 2002/04/05 10:00
PHST- 2002/04/05 10:00 [pubmed]
PHST- 2002/07/13 10:01 [medline]
PHST- 2002/04/05 10:00 [entrez]
AID - S0006899302022801 [pii]
AID - 10.1016/s0006-8993(02)02280-1 [doi]
PST - ppublish
SO  - Brain Res. 2002 Apr 19;933(2):98-108. doi: 10.1016/s0006-8993(02)02280-1.