PMID- 11932969
OWN - NLM
STAT- MEDLINE
DCOM- 20020503
LR  - 20190916
IS  - 0148-639X (Print)
IS  - 0148-639X (Linking)
VI  - 25
IP  - 4
DP  - 2002 Apr
TI  - Longitudinal study of functional spinal alpha motor neuron loss in amyotrophic 
      lateral sclerosis.
PG  - 520-6
AB  - Using a microstimulation technique for obtaining motor unit number estimates 
      (MUNEs) of the hypothenar and extensor digitorum brevis (EDB) muscles, we 
      performed a longitudinal study on the natural course of change in the clinical 
      rating scale (Appel score) and of loss of functional spinal alpha motor neurons 
      in amyotrophic lateral sclerosis. The Appel score increased to about 150% of 
      normal at 12 months after onset, about 225% at 18 months after onset, and about 
      370% at 24 months after onset. By contrast, MUNEs decreased to about 27% of 
      normal at 12 months after onset, about 12% at 18 months after onset, and about 5% 
      at 24 months after onset. The relative merits of these different approaches in 
      detecting changes in the disease process in its early phase are discussed.
FAU - Arasaki, K
AU  - Arasaki K
AD  - Department of Neurology, NTT East Kanto Medical Center, 5-9-22 Higashi-Gotanda, 
      Shinagawa-ku, Tokyo 141-0022, Japan. arasaki@kmc.mhc.east.ntt.co.jp
FAU - Kato, Y
AU  - Kato Y
FAU - Hyodo, A
AU  - Hyodo A
FAU - Ushijima, R
AU  - Ushijima R
FAU - Tamaki, M
AU  - Tamaki M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
SB  - IM
MH  - Action Potentials/physiology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amyotrophic Lateral Sclerosis/*pathology/physiopathology
MH  - Anterior Horn Cells/*pathology/physiopathology
MH  - Electromyography
MH  - Hand/innervation/physiopathology
MH  - Humans
MH  - Longitudinal Studies
MH  - Middle Aged
MH  - Muscle Contraction/physiology
MH  - Muscle Weakness/etiology/*physiopathology
MH  - Muscle, Skeletal/*physiopathology
MH  - Nerve Degeneration/*pathology/physiopathology
EDAT- 2002/04/05 10:00
MHDA- 2002/05/04 10:01
CRDT- 2002/04/05 10:00
PHST- 2002/04/05 10:00 [pubmed]
PHST- 2002/05/04 10:01 [medline]
PHST- 2002/04/05 10:00 [entrez]
AID - 10.1002/mus.10067 [pii]
AID - 10.1002/mus.10067 [doi]
PST - ppublish
SO  - Muscle Nerve. 2002 Apr;25(4):520-6. doi: 10.1002/mus.10067.