PMID- 11933043
OWN - NLM
STAT- MEDLINE
DCOM- 20020618
LR  - 20061115
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 68
IP  - 1
DP  - 2002 Apr 1
TI  - Promoting axonal regeneration in the central nervous system by enhancing the cell 
      body response to axotomy.
PG  - 1-6
AB  - Neurons projecting into the peripheral nervous system (PNS) regenerate their 
      axons after injury, in contrast to those confined to the central nervous system 
      (CNS). Both neuronal and nonneuronal factors contribute to the lack of CNS 
      regeneration. In this review we concentrate on the differential gene expression 
      response to axotomy in PNS vs. CNS neurons. In general CNS neurons fail to 
      up-regulate or sustain the expression of regeneration-associated proteins (RAGs), 
      including trophic factors and their receptors. The presumed lack of trophic 
      support of axotomized CNS neurons provided the rationale for the exogenous 
      application of trophic factors, either to the lesion site or to the cell bodies. 
      Here, we review our data on the application of trophic factors to rubrospinal and 
      corticospinal neurons. Cell body treatment of axotomized rubrospinal neurons with 
      brain-derived neurotrophic factor (BDNF) reversed atrophy, increased GAP-43 and 
      Talpha-1 tubulin mRNA expression, and promoted axonal regeneration into 
      peripheral nerve grafts. Importantly, BDNF cell body treatment was still 
      effective in the chronic setting, i.e., when initiated 1 year after injury, but 
      BDNF had no effect when applied to the chronic spinal cord injury site. The 
      ability to promote regeneration in chronically injured neurons will hopefully 
      contribute to the development of treatment strategies for chronic spinal 
      injuries.
CI  - Copyright 2002 Wiley-Liss, Inc.
FAU - Plunet, Ward
AU  - Plunet W
AD  - CORD (Collaboration on Repair Discoveries), University of British Columbia, 
      Vancouver, British Columbia, Canada.
FAU - Kwon, Brian K
AU  - Kwon BK
FAU - Tetzlaff, Wolfram
AU  - Tetzlaff W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (GAP-43 Protein)
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Axotomy
MH  - Central Nervous System/cytology/injuries/physiology
MH  - GAP-43 Protein/genetics
MH  - Gene Expression
MH  - Nerve Growth Factors/physiology
MH  - Nerve Regeneration/genetics/*physiology
MH  - Neurons/physiology
MH  - Peripheral Nervous System/cytology/physiology
RF  - 73
EDAT- 2002/04/05 10:00
MHDA- 2002/06/19 10:01
CRDT- 2002/04/05 10:00
PHST- 2002/04/05 10:00 [pubmed]
PHST- 2002/06/19 10:01 [medline]
PHST- 2002/04/05 10:00 [entrez]
AID - 10.1002/jnr.10176 [pii]
AID - 10.1002/jnr.10176 [doi]
PST - ppublish
SO  - J Neurosci Res. 2002 Apr 1;68(1):1-6. doi: 10.1002/jnr.10176.