PMID- 11933121
OWN - NLM
STAT- MEDLINE
DCOM- 20020627
LR  - 20191105
IS  - 0951-418X (Print)
IS  - 0951-418X (Linking)
VI  - 16
IP  - 2
DP  - 2002 Mar
TI  - Effect of ganhuangenin obtained from Scutellaria radix on the chemical mediator 
      production of peritoneal exudate cells and immunoglobulin E level of mesenteric 
      lymph node lymphocytes in Sprague-Dawley rats.
PG  - 166-70
AB  - We previously showed that ganhuangenin (GHG) has beneficial antioxidative 
      properties against lipid peroxidation in tissues of Sprague-Dawley (SD) rats. In 
      this study, the effect of GHG on immunoglobulin E (IgE), histamine and 
      leukotriene B(4) (LTB(4)) levels of cells isolated from SD rats was examined with 
      regard to the manifestation of the type I allergic reaction. We showed that GHG 
      inhibited the IgE production of mesenteric lymph node (MLN) lymphocytes. In the 
      presence or absence of concanavalin A (ConA), the concentration used did not 
      exert a toxic effect against MLN lymphocytes. Interestingly, the increase in the 
      IgE content and lipid peroxidation induced by ConA was alleviated in the presence 
      of GHG. Moreover, GHG also inhibited histamine release from the peritoneal 
      exudate cells stimulated with a calcium ionophore, A23187, or with the histamine 
      releaser, compound 48/80. In the case of LTB(4), GHG markedly inhibited its 
      release at a concentration of 100 microM. Thus, it is concluded that GHG may 
      block the common pathway for the release of histamine and LTB(4), and that the 
      IgE level is responsible for the lipid peroxidation induced by ConA.
CI  - Copyright 2002 John Wiley & Sons, Ltd.
FAU - Lim, Beong Ou
AU  - Lim BO
AD  - Graduate School of East-West Medical Science, Department of Medical Nutrition, 
      Kyunghee University, 1 Hoeki-Dong, Dongdaemoon-Ku, Seoul 130-701, Korea. 
      beongou@nms.kyunghee.ac.kr
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Flavonoids)
RN  - 0 (Ionophores)
RN  - 0 (Plant Lectins)
RN  - 11028-71-0 (Concanavalin A)
RN  - 1HGW4DR56D (Leukotriene B4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 37H9VM9WZL (Calcimycin)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 820484N8I3 (Histamine)
RN  - 92519-91-0 (ganhuangenin)
SB  - IM
MH  - Animals
MH  - Ascitic Fluid/chemistry
MH  - Calcimycin/pharmacology
MH  - Concanavalin A/pharmacology
MH  - Drugs, Chinese Herbal
MH  - Flavonoids/chemistry/*pharmacology
MH  - Histamine/metabolism
MH  - Immunoglobulin E/*drug effects/metabolism
MH  - Ionophores/pharmacology
MH  - *Lamiaceae
MH  - Leukotriene B4/metabolism
MH  - Lipid Peroxidation/drug effects
MH  - Lymph Nodes/drug effects
MH  - Lymphocytes/*drug effects/immunology
MH  - Mesentery/drug effects
MH  - Plant Lectins
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 2002/04/05 10:00
MHDA- 2002/06/28 10:01
CRDT- 2002/04/05 10:00
PHST- 2002/04/05 10:00 [pubmed]
PHST- 2002/06/28 10:01 [medline]
PHST- 2002/04/05 10:00 [entrez]
AID - 10.1002/ptr.1034 [pii]
AID - 10.1002/ptr.1034 [doi]
PST - ppublish
SO  - Phytother Res. 2002 Mar;16(2):166-70. doi: 10.1002/ptr.1034.