PMID- 11936276
OWN - NLM
STAT- MEDLINE
DCOM- 20020927
LR  - 20191025
IS  - 0893-5785 (Print)
IS  - 0893-5785 (Linking)
VI  - 15
IP  - 2
DP  - 2002 Apr
TI  - The expression of corticotropin-releasing hormone in melanoma.
PG  - 98-103
AB  - We previously demonstrated that advanced melanoma cells express high amounts of 
      proopiomelanocortin (POMC) that correlate with tumor progression. We now 
      investigated whether the high expression of POMC derives from increased 
      expression of corticotropin-releasing hormone (CRH) and the possible role of CRH 
      as a melanoma growth factor. Forty-five cases of melanoma [25 primary malignant 
      melanoma; 20 metastatic melanoma (MetM)] were immunohistochemically analysed for 
      coexpression of POMC and CRH peptides. The ability of CRH to induce POMC 
      expression in cultured melanoma cells was examined using CRH and a CRH 
      antagonist. In CRH positive melanomas, seven out of nine cases (78%) of primary 
      melanoma, and 7 out of 12 cases (58%) of MetM showed colocalization of CRH and 
      POMC peptides. CRH induced POMC mRNA expression, an effect that was inhibited by 
      a CRH antagonist. These results provide evidence for the existence of the 
      CRH/POMC axis in pigmented lesions.
FAU - Sato, Hirofumi
AU  - Sato H
AD  - Department of Dermatology, Kobe University School of Medicine, Japan.
FAU - Nagashima, Yoji
AU  - Nagashima Y
FAU - Chrousos, George P
AU  - Chrousos GP
FAU - Ichihashi, Masamitsu
AU  - Ichihashi M
FAU - Funasak, Yoko
AU  - Funasak Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Pigment Cell Res
JT  - Pigment cell research
JID - 8800247
RN  - 0 (Hormone Antagonists)
RN  - 0 (Peptide Fragments)
RN  - 66796-54-1 (Pro-Opiomelanocortin)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - 96118-75-1 (corticotropin releasing hormone (9-41))
SB  - IM
MH  - Corticotropin-Releasing Hormone/antagonists & 
      inhibitors/*biosynthesis/genetics/pharmacology
MH  - Gene Expression Regulation, Neoplastic
MH  - Hormone Antagonists/pharmacology
MH  - Humans
MH  - Melanoma/drug therapy/*metabolism/pathology
MH  - Neoplasm Metastasis
MH  - Peptide Fragments/pharmacology
MH  - Pro-Opiomelanocortin/*biosynthesis/genetics
MH  - Skin/drug effects/metabolism/pathology
MH  - Tumor Cells, Cultured
EDAT- 2002/04/09 10:00
MHDA- 2002/09/28 04:00
CRDT- 2002/04/09 10:00
PHST- 2002/04/09 10:00 [pubmed]
PHST- 2002/09/28 04:00 [medline]
PHST- 2002/04/09 10:00 [entrez]
AID - 10.1034/j.1600-0749.2002.1o063.x [doi]
PST - ppublish
SO  - Pigment Cell Res. 2002 Apr;15(2):98-103. doi: 10.1034/j.1600-0749.2002.1o063.x.