PMID- 11936688
OWN - NLM
STAT- MEDLINE
DCOM- 20021001
LR  - 20190922
IS  - 1570-0232 (Print)
IS  - 1570-0232 (Linking)
VI  - 769
IP  - 1
DP  - 2002 Mar 25
TI  - Human blood and environmental media screening method for pesticides and 
      polychlorinated biphenyl compounds using liquid extraction and gas 
      chromatography-mass spectrometry analysis.
PG  - 155-67
AB  - Screening assessment methods have been developed for semi- and non-volatile 
      persistent organic pollutants (POPs) for human blood and solid environmental 
      media. The specific methodology is developed for measuring the presence of 
      "native" compounds, specifically, a variety of organochlorine pesticides (OCPs), 
      organophosphate pesticides (OPPs), and for polychlorinated biphenyls (PCBs). The 
      method is demonstrated on anonymous Red Cross blood samples as well as two 
      potential environmental sources, tracked in soil and dog hair. This work is based 
      on previously developed methods for semi-volatile hydrocarbon exposure from fuels 
      usage and similarly employs liquid solvent extraction, evaporative volume 
      reduction. and subsequent specialized gas chromatography-mass spectrometry 
      analysis (GC-MS). Standard curves, estimates of recovery efficiency, and specific 
      GC-MS SIM quantification methods were developed for common pesticides including 
      diazinon. aldrin, chlorpyrifos, malathion, dieldrin, DDT, permethrin, 
      cyhalothrin, and cypermethrin, and for seven selected PCBs. Trace levels of 
      certain PCBs and pesticides such as permethrin, dieldrin, malathion, lindane, 
      diazinon, and chlorpyrifos were tentatively identified in anonymous blood samples 
      as well as in two potential environmental sources. tracked in soil and dog hair. 
      The method provides a simple screening procedure for various media and a variety 
      of common organic pollutants without extensive sample preparation. It is meant to 
      complement and augment data from more specific or complex methodology, to provide 
      initial broad spectrum guidance for designing targeted experiments, and to 
      provide confirmatory evidence for the usual metabolic biomarker measurements made 
      to assess human exposure.
FAU - Liu, Siming
AU  - Liu S
AD  - ManTech Environmental Technology, Inc, Research Triangle Park, NC 27709, USA.
FAU - Pleil, Joachim D
AU  - Pleil JD
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Environmental Monitoring/*methods
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Hair/chemistry
MH  - Humans
MH  - Pesticides/*analysis/blood
MH  - Polychlorinated Biphenyls/*analysis/blood
EDAT- 2002/04/09 10:00
MHDA- 2002/10/03 04:00
CRDT- 2002/04/09 10:00
PHST- 2002/04/09 10:00 [pubmed]
PHST- 2002/10/03 04:00 [medline]
PHST- 2002/04/09 10:00 [entrez]
AID - S1570-0232(01)00640-7 [pii]
AID - 10.1016/s1570-0232(01)00640-7 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Mar 25;769(1):155-67. doi: 
      10.1016/s1570-0232(01)00640-7.