PMID- 11937763
OWN - NLM
STAT- MEDLINE
DCOM- 20020917
LR  - 20220224
IS  - 1018-7782 (Print)
IS  - 1018-7782 (Linking)
VI  - 10
IP  - 2
DP  - 2002
TI  - Endothelial gene responses to homocysteine: relation to atherosclerosis.
PG  - 164-9
AB  - Chronic renal failure is associated with a 20-fold increased risk of 
      cardiovascular mortality, in part due to accelerated atherosclerosis. 
      Hyperhomocysteinemia (HHCy) is common in patients with chronic renal failure. It 
      has been established that HHCy is an independent and graded risk factor for 
      atherosclerosis, though the mechanisms responsible for it remain obscure. Using 
      the cardiovascular cDNA microarray approach, we screened the expression of 600 
      cardiovascular relevant genes in human umbilical endothelial cells and identified 
      a number of homocysteine-modulated genes. These differentially displayed genes 
      were classified according to the functional outcome of their encoded proteins: 
      endothelial motility cluster, signaling cluster, and lipid metabolism cluster. 
      The results may be relevant to understanding the mechanisms underlying the 
      pathophysiological effects of HHCy, particularly those leading to endothelial 
      dysfunction and the pathogenesis of atherosclerosis.
CI  - Copyright 2002 S. Karger AG, Basel
FAU - Li, Hong
AU  - Li H
AD  - Department of Physiology and Biophysics, State University of New York, Stony 
      Brook, N.Y., USA.
FAU - Goligorsky, Michael S
AU  - Goligorsky MS
LA  - eng
GR  - DK 45462/DK/NIDDK NIH HHS/United States
GR  - DK 52783/DK/NIDDK NIH HHS/United States
GR  - DK 54602/DK/NIDDK NIH HHS/United States
GR  - T32 DK 07521-14/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Switzerland
TA  - Exp Nephrol
JT  - Experimental nephrology
JID - 9302239
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Arteriosclerosis/*genetics/metabolism
MH  - Homocysteine/*genetics/metabolism
MH  - Humans
MH  - Kidney Failure, Chronic/genetics/metabolism
MH  - *Oligonucleotide Array Sequence Analysis
RF  - 31
EDAT- 2002/04/09 10:00
MHDA- 2002/09/18 10:01
CRDT- 2002/04/09 10:00
PHST- 2002/04/09 10:00 [pubmed]
PHST- 2002/09/18 10:01 [medline]
PHST- 2002/04/09 10:00 [entrez]
AID - 49911 [pii]
AID - 10.1159/000049911 [doi]
PST - ppublish
SO  - Exp Nephrol. 2002;10(2):164-9. doi: 10.1159/000049911.