PMID- 11941417
OWN - NLM
STAT- MEDLINE
DCOM- 20021210
LR  - 20131121
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 52
IP  - 6
DP  - 2000 Dec
TI  - [Relationship between memory enhancement induced by nitric oxide donor and brain 
      ADP-ribosyltransferase in rats].
PG  - 507-10
AB  - In order to explore the signal transduction pathway of nitric oxide (NO) related 
      to learning and memory, the effects of intracerebral ventricular injection (icv) 
      of NO donor sodium nitroprusside (SNP) alone or along with ADP-ribosyltransferase 
      (ADPRT) inhibitor nicotinamide (NIC) on learning and memory behavior were 
      investigated in rats. Brain ADPRT activity was analyzed using high performance 
      liquid chromatography. The results showed that SNP (0.36 microgram, icv) 
      facilitated short-term and long-term memory in passive avoidance response and 
      elevated learning and memory ability in active avoidance response. NIC (1.5 mg, 
      icv) blocked the effect of SNP. Training in active avoidance task raised ADPRT 
      activity in hippocampus. Treatment with SNP (icv) before training caused 
      significant elevation of ADPRT activity in hippocampus and cerebral cortex. The 
      results above support the view that ADPRT may be one of the target molecules of 
      NO action.
FAU - Li, C D
AU  - Li CD
AD  - Medical School, Hubei Three Canyon University, Yichang 443003, China.
FAU - Zhang, S Y
AU  - Zhang SY
FAU - Yuan, B
AU  - Yuan B
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 0 (Nitric Oxide Donors)
RN  - 169D1260KM (Nitroprusside)
RN  - 25X51I8RD4 (Niacinamide)
RN  - EC 2.4.2.- (ADP Ribose Transferases)
SB  - IM
MH  - ADP Ribose Transferases/antagonists & inhibitors/*metabolism
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Brain/*enzymology
MH  - Chromatography, High Pressure Liquid
MH  - Male
MH  - Memory/*drug effects
MH  - Niacinamide/pharmacology
MH  - Nitric Oxide Donors/*pharmacology
MH  - Nitroprusside/pharmacology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
EDAT- 2002/04/10 10:00
MHDA- 2002/12/11 04:00
CRDT- 2002/04/10 10:00
PHST- 2002/04/10 10:00 [pubmed]
PHST- 2002/12/11 04:00 [medline]
PHST- 2002/04/10 10:00 [entrez]
PST - ppublish
SO  - Sheng Li Xue Bao. 2000 Dec;52(6):507-10.