PMID- 11943506
OWN - NLM
STAT- MEDLINE
DCOM- 20020827
LR  - 20190922
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 24
IP  - 2
DP  - 2002 Mar-Apr
TI  - Long-lasting effects of prenatal MAM treatment on water maze performance in rats: 
      associations with altered brain development and neurotrophin levels.
PG  - 179-91
AB  - We previously reported that prenatal methylazoxymethanol (MAM) administered on 
      days 11 and 12 of rat pregnancy induces structural changes in the 
      cytoarchitecture of the hippocampal-entorhinal axis. We also showed that young 
      and middle-aged prenatally treated MAM animals displayed changes in brain 
      neurotrophin levels [Neurosci. Lett. 309 (2001) 113; Physiol. Behav. 71 (2000) 
      57.]. To continue this line of investigation, the working hypothesis adopted was 
      that prenatal MAM administration, by interfering with limbic neurogenesis, could 
      impair learning and memory ability of aged animals in the water maze. It was 
      found that injection of MAM during early rat brain development induced deficits 
      in both the acquisition and retention phases of the Morris maze. These behavioral 
      changes were associated with significant changes in brain nerve growth factor 
      (NGF) and brain-derived neurotrophic factor (BDNF), reduced choline 
      acetyltransferase (ChAT) immunoreactivity in forebrain cholinergic neurons and 
      loss of neuropeptide Y (NPY) immunodistribution in cells of the entorhinal 
      cortex. This finding, as well as confirming previous studies showing that 
      injection of prenatal MAM administration induces significant changes in 
      hippocampal-entorhinal axis neurogenesis and marked behavioral deficits in adult 
      life, provides additional experimental evidence supporting the hypothesis that 
      loss of NGF and/or BDNF-receptive or producing cells can co-occur at the onset of 
      neurodevelopmental disorders.
FAU - Fiore, Marco
AU  - Fiore M
AD  - Istituto di Neurobiologia e Medicina Molecolare, CNR, Viale Marx, 43/15, 00137 
      Rome, Italy.
FAU - Korf, Jakob
AU  - Korf J
FAU - Antonelli, Alessia
AU  - Antonelli A
FAU - Talamini, Lucia
AU  - Talamini L
FAU - Aloe, Luigi
AU  - Aloe L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Teratogens)
RN  - 592-62-1 (Methylazoxymethanol Acetate)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - EC 2.3.1.6 (Choline O-Acetyltransferase)
RN  - JGG19N3YDQ (methylazoxymethanol)
SB  - IM
MH  - Animals
MH  - Basal Ganglia/metabolism
MH  - Brain/growth & development/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Choline O-Acetyltransferase/metabolism
MH  - Entorhinal Cortex/cytology/metabolism
MH  - Female
MH  - Hippocampus/cytology/metabolism
MH  - Immunohistochemistry
MH  - Maze Learning/*drug effects
MH  - Methylazoxymethanol Acetate/*analogs & derivatives/*toxicity
MH  - Nerve Growth Factor/*metabolism
MH  - Neurons/enzymology
MH  - Neuropeptide Y/metabolism
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Wistar
MH  - Teratogens/*toxicity
EDAT- 2002/04/12 10:00
MHDA- 2002/08/28 10:01
CRDT- 2002/04/12 10:00
PHST- 2002/04/12 10:00 [pubmed]
PHST- 2002/08/28 10:01 [medline]
PHST- 2002/04/12 10:00 [entrez]
AID - S0892036201002148 [pii]
AID - 10.1016/s0892-0362(01)00214-8 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2002 Mar-Apr;24(2):179-91. doi: 
      10.1016/s0892-0362(01)00214-8.