PMID- 11943826
OWN - NLM
STAT- MEDLINE
DCOM- 20020422
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 22
IP  - 8
DP  - 2002 Apr 15
TI  - Brain-derived neurotrophic factor produces antidepressant effects in behavioral 
      models of depression.
PG  - 3251-61
AB  - Previous studies demonstrated that antidepressant treatment increases the 
      expression of brain-derived neurotrophic factor (BDNF) in rat hippocampus. The 
      present study was conducted to test the hypothesis that BDNF in the hippocampus 
      produces an antidepressant effect in behavioral models of depression, the learned 
      helplessness (LH) and forced swim test (FST) paradigms. A single bilateral 
      infusion of BDNF into the dentate gyrus of hippocampus produced an antidepressant 
      effect in both the LH and FST that was comparable in magnitude with repeated 
      systemic administration of a chemical antidepressant. These effects were observed 
      as early as 3 d after a single infusion of BDNF and lasted for at least 10 d. 
      Similar effects were observed with neurotrophin-3 (NT-3) but not nerve growth 
      factor. Infusions of BDNF and NT-3 did not influence locomotor activity or 
      passive avoidance. The results provide further support for the hypothesis that 
      BDNF contributes to the therapeutic action of antidepressant treatment.
FAU - Shirayama, Yukihiko
AU  - Shirayama Y
AD  - Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, 
      Connecticut Mental Health Center, Yale University School of Medicine, New Haven, 
      Connecticut 06508, USA.
FAU - Chen, Andrew C-H
AU  - Chen AC
FAU - Nakagawa, Shin
AU  - Nakagawa S
FAU - Russell, David S
AU  - Russell DS
FAU - Duman, Ronald S
AU  - Duman RS
LA  - eng
GR  - P01 MH025642/MH/NIMH NIH HHS/United States
GR  - MH45481/MH/NIMH NIH HHS/United States
GR  - R37 MH045481/MH/NIMH NIH HHS/United States
GR  - 2PO1 MH25642/MH/NIMH NIH HHS/United States
GR  - R01 MH045481/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Brain-Derived Neurotrophic Factor/*administration & dosage
MH  - Dentate Gyrus/drug effects/enzymology
MH  - Depression/*drug therapy
MH  - Disease Models, Animal
MH  - Electroshock
MH  - Enzyme Inhibitors/administration & dosage
MH  - Escape Reaction/drug effects
MH  - Helplessness, Learned
MH  - Hippocampus/drug effects/enzymology
MH  - Immunohistochemistry
MH  - Male
MH  - Microinjections
MH  - Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism
MH  - Motor Activity/drug effects
MH  - Nerve Growth Factor/administration & dosage
MH  - Neurotrophin 3/administration & dosage
MH  - Proto-Oncogene Proteins c-fos/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reaction Time/drug effects
MH  - Spatial Behavior/drug effects
PMC - PMC6757539
EDAT- 2002/04/12 10:00
MHDA- 2002/04/23 10:01
PMCR- 2002/10/15
CRDT- 2002/04/12 10:00
PHST- 2002/04/12 10:00 [pubmed]
PHST- 2002/04/23 10:01 [medline]
PHST- 2002/04/12 10:00 [entrez]
PHST- 2002/10/15 00:00 [pmc-release]
AID - 22/8/3251 [pii]
AID - 6292 [pii]
AID - 10.1523/JNEUROSCI.22-08-03251.2002 [doi]
PST - ppublish
SO  - J Neurosci. 2002 Apr 15;22(8):3251-61. doi: 10.1523/JNEUROSCI.22-08-03251.2002.